肺癌患者血浆热休克蛋白90α的表达及意义  

The expression of plasma heat shock protein HSP90α and its clinical significance for lung cancer patients

作　　者：江倩[1] 金蒙蒙[1] 黄锐[1] 刘茵[1] 杜婷[1] 张妍蓓[1] 

机构地区：[1]安徽医科大学第一附属医院老年医学呼吸内科,合肥市230022

出　　处：《实用医学杂志》2016年第13期2129-2132,共4页The Journal of Practical Medicine

基　　金：安徽省教育厅重点项目(编号:KJ2011A178);安徽省科技厅自然基金重点项目(编号:1208085MH146);安徽省15年第一批科技攻关项目(编号:1501041144)

摘　　要：目的：探讨肺癌患者血浆热休克蛋白90仅（HSP90α）的表达及其临床意义。方法：应用酶联免疫法检测60例初治肺癌患者及24例健康体检者血浆HSP90α浓度，并分析患者临床资料。结果：肺癌组血浆HSP90cx浓度[（190．338±105．861）ng／mL]明显高于健康对照组[（41．020±19．736）ng／mL，t=10．480．P〈0．001]；与CEA、NSE、CYFRA21—1相比，HSP90α灵敏度更高，包括血清胸苷激酶1（STK1）在内的五项联合检测灵敏度达100％；HSP90α与STK1表达（x^2=3．914，P=0．048）、是否发生远处转移（x^2=4．656．P：0．031）有关。结论：HSP90α具有辅助诊断肺癌的作用，其联合肺癌三项及STK1可显著提高肺癌的检出率。Objective To explore the expression plasma heat shock protein HSP90α and its clinical signifi- cance for lung cancer patients. Methods Plasma levels of HSP90α protein of 60 patients with lung cancer and 24 healthy individuals are detected by ELISA analysis. Results The average plasma levels of HSP90et protein [ （190.338 ± 105.861） ng/mL] in patients with lung cancer were significantly higher than in healthy con- trols [（41.020 ± 19.736） ng/mL, t = 10.480, P 〈 0.001]. The sensitivity of HSP90α is higher than CEA, NSE, CYFRA21-1. The sensitivity of HSP90α, CEA, NSE, CYFRA21-1 and STK1 is 100%. HSP90α is correlated with STK1 and metastasis （x^2 = 4.656, P = 0.031）. Conclusions This study demonstrates that the plasma level of HSP90α protein is a useful diagnostic biomarker in lung cancer. The sensitivity is much higher when HSP90α com- bined with CEA, NSE, CYFRA21-1 and STK1.

关 键 词：热休克蛋白90Α 肺恶性肿瘤 临床特征 联合检测 

分 类 号：R734.2[医药卫生—肿瘤]