老年抑郁症患者血清IL-6、IL-8水平及其与认知功能的关系研究  

The Analysis of Serum Levels of IL-6 and IL-8 and Relationship with Cognitive Function in Late-Life Depression

作　　者：钟笑梅[1] 王艳华[1] 吴章英[1] 陈贲[1] 彭琪[1] 陈辛茹[1] 张蔚茹[1] 欧阳聪[1] 宁玉萍[1] 

机构地区：[1]广州市惠爱医院/广州医科大学附属脑科医院神经科,广东广州510370

出　　处：《临床医学工程》2016年第7期943-945,共3页Clinical Medicine & Engineering

基　　金：国家自然科学基金面上项目(81571333);广州市科技计划项目2015年科学研究专项(1563000496);广州市医药卫生科技项目(20141A011044)

摘　　要：目的探索老年抑郁症患者(LLD)在不同疾病状态下血清IL-6、IL-8水平的特点及其认知功能损害与炎性因子水平的关系。方法共纳入被试109例,其中LLD发作期24例,LLD恢复期20例,遗忘型轻度认知障碍(a MCI)患者45例,正常对照20例。使用汉密尔顿抑郁量表17项(HAMD-17)评定抑郁症状,简易智能状态量表(MMSE)评定认知功能。使用人定量ELISA试剂盒测定血清IL-6、IL-8水平。结果 LLD发作期患者血清IL-8水平[8.46(9.67)pg/m L]高于a MCI[6.97(3.63)pg/m L]及正常对照[6.71(5.03)pg/m L],差异有统计学意义(均P<0.05);LLD发作期伴认知损害患者血清IL-8水平[8.51(10.93)pg/m L]、LLD恢复期伴认知损害患者血清IL-8水平[9.24(27.04)pg/m L]均显著高于a MCI及正常对照(均P<0.05)。LLD发作期伴认知损害患者血清IL-6水平[1.13(1.61)pg/m L]高于a MCI组[0.71(0.61)pg/m L],差异有统计学意义(P<0.01)。结论恢复期LLD伴认知损害患者存在免疫失衡,慢性炎症状态可能是其持续认知损害的影响因素。Objective To investigate the serum levels of IL-6 and IL-8 in different disease states of late-life depression（LLD）, and explore the relationship between proinflammatory cytokines and cognitive impairment. Methods A total of 1 09 subjects were included（24LLD patients in episode stage, 20 remitted LLD patients, 45 a MCI patients and 20 normal controls）. The mini mental state examination（MMSE） was used to assess the cognitive function, and 1 7-item H amilton depression rating scale（HDRS） was used to assess the severity of depressive symptoms. Serum IL-6 and IL-8 levels were measured by E L ISA. Results Serum IL-8 level of LLD patients in episode stage[8.46（9.67） pg/m L ] was significantly higher than that in a MCI patients [6.97（3.63） pg/mL ] and normal controls [6.71（5.03） pg/m L ]（all P〈0.05）. The serum IL-8 levels in LLD patients with cognitive impairment in episode stage [8.51（10.93） pg/m L ] and those with cognitive impairment in remitted stage [9.24（27.04） pg/m L ] were significantly higher than a MCI patients and normal controls（all P〈0.05）. Serum IL-6 level in LLD patients with cognitive impairment in episode stage [1.13（1.61） pg/mL ] was higher than that in a MCI paitnes [0.71（0.61）pg/m L ]（P〈0.01）. Conclusions R emitted LLD patients with cognitive impairment are associated with immune imbalance. Chronic inflammation may contribute to the persistent cognitive impairment in LLD patients.

关 键 词：老年抑郁症 发作期 恢复期 认知损害 免疫失衡 

分 类 号：R749.41[医药卫生—神经病学与精神病学]