人口腔黏膜鳞癌进展中胶原纤维变化的研究  

Changes of collagen fibers in the development of human oral squamous cell carcinoma

作　　者：赵红[1] 孙苗[2] 陈东[2] 郑金华[3] 

机构地区：[1]哈尔滨医科大学口腔医学院口腔组织病理教研室,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属口腔医院口腔外科,黑龙江哈尔滨150001 [3]哈尔滨医科大学解剖学教研室,黑龙江哈尔滨150081

出　　处：《口腔医学》2016年第7期595-598,共4页Stomatology

摘　　要：目的探讨人口腔黏膜鳞癌发展过程中胶原纤维形态和含量与肿瘤进展的关系。方法采用HE和Masson三色染色分析80例人口腔黏膜鳞癌标本中胶原纤维的表达情况,并对胶原纤维的表达量及其与肿瘤分化的相关性进行统计学分析。结果与正常黏膜相比,重度不典型增生组织发生黏膜下沉积;胶原纤维形态与分布在侵袭性不同的浸润癌和高、中、低分化癌中呈减少的趋势。各组间胶原纤维面积百分比差异显著(P<0.05),肿瘤分化程度与肿瘤进展呈负相关(相关系数r=-0.800)。结论胶原纤维的形态分布与口腔黏膜癌的演进及分化程度密切相关。Objective To investigate the relationship between the morphology and content of collagen fibers and the development of tumor in human oral squamous carcinoma. Methods Paraffin sections from the 80 clinical specimens of oral squamous cell carcinoma that were stained with HE and Masson’ s trichrome stain were observed for collagen fibers under the microscope. Statistical analysis was used to analyze the expression of collagen fiber and its correlation with tumor differentiation. Results Oral submucous fiber deposition was observed in severe atypical hyperplasia. The morphology and distribution of collagen fibers obviously decreased in infiltrating carci-noma with different invasiveness as well as in highly, moderately and lowly differentiated carcinomas. The difference in collagen per ar-ea among groups was statistically significant （ P〈0.05） , and the tumor differentiation degree was negatively related to the tumor pro-gression（ r=-0.800, P〈0.05） . Conclusion The distribution and morphology of collagen fibers are closely related to the development of human oral mucous carcinoma and the differentiation degree of carcinomas.

关 键 词：胶原纤维 口腔黏膜癌 MASSON染色 

分 类 号：R780.2[医药卫生—口腔医学]