Fabrication of ultrathin Zn（OH）2 nanosheets as drug carriers  

作　　者：Ren Cai Dan Yang Jin Wu Liqin Zhang Cuichen Wu Xigao Chen Yanyue Wang Shuo Wan Fengwei HOU Qingyu Yan Weihong Tan 

机构地区：[1]Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA [2]Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Molecular Engineering and Theranostics, Hunan University, Changsha 410082, China [3]School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore

出　　处：《Nano Research》2016年第8期2520-2530,共11页纳米研究（英文版）

基　　金：The authors are grateful to Dr. Kathryn Williams for her critical comments during the preparation of this manuscript. This work is supported by grants awarded by the National Institutes of Health （No. GM079359 and CA133086）. This work is also supported by the National Basic Research Program of China （No. 2011CB911000）, National Natural Science Foundation of China （Nos. 21221003 and 21327009） and China National Instrumentation Program （No. 2011YQ03012412）.

摘　　要：Ultrathin two-dimensional （2D） porous Zn（OH）2 nanosheets （PNs） were fabricated by means of one-dimensional Cu nanowires as backbones. The PNs have thickness of approximately 3.8 nm and pore size of 4-10 nm. To form ＂smart＂ porous nanosheets, DNA aptamers were covalently conjugated to the surface of PNs. These ultrathin nanosheets show good biocompatibility, effident cellular uptaker and promising pH-stimulated drug release.Ultrathin two-dimensional （2D） porous Zn（OH）2 nanosheets （PNs） were fabricated by means of one-dimensional Cu nanowires as backbones. The PNs have thickness of approximately 3.8 nm and pore size of 4-10 nm. To form ＂smart＂ porous nanosheets, DNA aptamers were covalently conjugated to the surface of PNs. These ultrathin nanosheets show good biocompatibility, effident cellular uptaker and promising pH-stimulated drug release.

关 键 词：APTAMER porous Zn（OH）2 nanosheets cancer cell cell-targeted delivery 

分 类 号：O[理学]