肠、肝脂肪酸结合蛋白在肠梗阻诊断中的意义  

Diagnostic significance of serum intestinal fatty acid-binding protein and intestinal fatty acid-binding protein for intestinal obstruction patients

作　　者：张传宝[1] 张敬坡[1] 冯雷[1] 郑韬[1] 秦静[1] 

机构地区：[1]石家庄市第三医院普外二科,石家庄050017

出　　处：《山西医科大学学报》2016年第7期608-610,共3页Journal of Shanxi Medical University

摘　　要：目的探讨肠脂肪酸结合蛋白(IFABP)、肝脂肪酸结合蛋白(LFABP)在肠梗阻诊断中的意义。方法选肠梗阻患者31例,分为两组:切除肠管组(肠坏死手术切除肠管)13例、未切除肠管组(行开腹手术未切除肠管)18例。所有患者在入院时、术后第1日、术后第7日采静脉血,检测血清IFABP及LFABP的含量;取正常体检者15例作为对照组,采静脉血1次,检测血清IFABP、LFABP含量。结果所有肠梗阻患者入院时血清IFABP及LFABP水平均高于对照组(P<0.01),并且切除肠管组IFABP及LFABP水平高于未切除肠管组(P<0.01)。术后第1日,两研究组血清IFABP水平均降至正常(P>0.05),切除肠管组LFABP水平较入院时降低(P<0.05),但仍高于对照组(P<0.05),未切除肠管组LFABP水平降至正常(P>0.05)。术后第7日,两研究组血清IFABP、LFABP水平较对照组差异无统计学意义(P>0.05)。结论血清IFABP及LFABP均是诊断肠缺血严重程度的敏感指标。Objective To explore the significance of serum intestinal fatty acid-binding protein（ IFABP） and liver fatty acid-binding protein（LFABP） in diagnosis of the intestinal obstruction. Methods Totally 31 patient with intestinal obstruction were chosen and divided into two groups： enterectomy＋anastomosis group（n=13） and celiotomy group（n=18）. Fifteen healthy people were chosen as control group. Venous blood was collected on admission,at 1,7 day after operation in intestinal obstruction patients and only once in controls. The concentrations of serum IFABP and LFABP were measured. Results On admission,the levels of serum IFABP and LFABP were significantly higher in two study groups than in control group（ P〈0.01）,and the levels in enterectomy ＋ anastomosis group were also higher than in celiotomy group（ P〈0.01）. At 1 day after operation,the levels of IFABP in two study groups decreased to the normal（ P〈0.05）. At 1 day,the level of LFABP in enterectomy ＋ anastomosis group was decreased（ P〈0.05）,but it was also higher than in control group（ P〈0. 05）,while the level of LFABP in celiotomy group decreased to the normal（ P〈0.05）. At 7 day after operation,the levels of serum IFABP and LFABP in two study groups showed no significant difference between two study groups and control group（ P〈0.05）. Conclusion Both serum IFABP and LFABP are sensitive markers to diagnose the serious degree of intestinal ischemia.

关 键 词：肠脂肪酸结合蛋白 肝脂肪酸结合蛋白 肠梗阻 

分 类 号：R574.2[医药卫生—消化系统]