非酒精性脂肪肝患者空腹及餐后游离脂肪酸与胰岛素抵抗的关系  

Relationship between the Fasting Levels and Levels after Diet of Free Fatty Acid with Insulin Resistance in Non-alcoholic Fatty Liver Disease Patients

作　　者：张凤[1] 

机构地区：[1]内江市第一人民医院消化科,四川内江641000

出　　处：《中国医药指南》2016年第18期26-27,共2页Guide of China Medicine

摘　　要：目的探讨非酒精性脂肪肝(NAFLD)患者空腹及餐后2 h游离脂肪酸(FFA)水平及其与胰岛素抵抗的相关性。方法检测45例NAFLD患者及40例正常对照组空腹血糖、胰岛素、三酰甘油、胆固醇、FFA及餐后2h FFA,用HOMA-IR评估胰岛素抵抗。结果与对照组相比,NAFLD患者HOMA-IR、空腹及餐后FFA水平显著增高,且空腹及餐后FFA与HOMA-IR呈显著正相关。结论 NAFLD患者空腹及餐后增高的FFA水平与胰岛素抵抗密切相关。Objective To determine the fasting levels and levels after diet of free fatty acid（FFA） and its relationship to insulin resistance in non-alcoholic fatty liver disease（NAFLD） patients. Methods 45 NAFLD and 40 healthy controls were evaluated. Fast glucose, insulin, triglyceride, total cholesterol, FFA and 2 h FFA were tested for each subject. Homeostasis model assessment of insulin resistance（HOMA-IR）was calculated. Results The levels of HOMA-IR, fasting FFA and 2 h FFA were significantly higher in patients with NAFLD than those in healthy controls. FFA and 2 h FFA were positively associated with HOMA-IR. Conclusions Increased fasting and 2 h FFA levels are associated with insulin resistance in NAFLD.

关 键 词：游离脂肪酸 胰岛素抵抗 非酒精性脂肪肝 

分 类 号：R575[医药卫生—消化系统]