Ph^+急性淋巴细胞白血病CNSL早期脑脊液蛋白标志物的筛选  

Screening of Ph^+ early cerebrospinal fluid protein markers of acute lymphoblastic leukemia patients with CNSL

作　　者：田文洪[1] 王晓燕[1] 蔡艳霞[1] 王少彬[1] 张志[1] 

机构地区：[1]深圳市福田区人民医院血液内科,广东深圳518033

出　　处：《现代医学》2016年第6期816-818,共3页Modern Medical Journal

摘　　要：目的:利用蛋白质组学质谱分析技术寻找出Ph阳性急性淋巴细胞白血病(Ph+ALL)患者发生中枢神经系统白血病(CNSL)早期的脑脊液诊断标志物。方法:分别收集16例CNSL患者和18例病毒性脑膜炎患者,在治疗前、治疗后、疾病缓解期3个不同的时期收集样本并进行相应的处理。结果:脑膜炎组和CNSL组在治疗开始前的数据中有11个蛋白质峰有明显的差异;CNSL组治疗开始前和病情缓解期两个时期有4个蛋白质峰有非常大的差异。结论:使用蛋白质组学质谱分析技术能够快速找到Ph+ALL患者发生CNSL早期的脑脊液诊断标志物。Objective： To find early cerebrospinal fluid protein markers of central nervous system leukemia（ CNSL） of Ph positive acute lymphoblastic leukemia（ Ph^＋ALL） patients by using proteomics analysis technique.Methods： 16 patients with CNSL and 18 cases of viral meningitis were respectively collected,during three different periods of treatment, before and after treatment, the disease remission stage, samples were collected and corresponding processing was carried out. Results： Eleven protein peaks had very significant differences in the data before treatment between the meningitis group and the CNSL group; Four protein peaks had significant differences between before treatment and disease remission stage in CNSL group. Conclusions： There is a very significant effect on finding early cerebrospinal fluid protein markers of CNSL of Ph^＋ALL patients by using proteomics analysis technique.

关 键 词：蛋白标志物 急性淋巴细胞 脑脊液 中枢神经系统白血病 

分 类 号：R733.71[医药卫生—肿瘤]