单核苷酸多态性rs1885068与卒中及其亚型患病风险的关系  

Association of Single Nucleotide Polymorphism Rs1885068 with Stroke Subtypes Prognosis

作　　者：吴涛 邱石 宋莉[2] 宋燕[2] 张银辉[2] 陈敬洲[2] 杜继臣 

机构地区：[1]北京大学航天临床医学院,北京市100049 [2]北京协和医学院中国医学科学院国家心血管病中心阜外医院心血管病国家实验室,北京市100037

出　　处：《中国分子心脏病学杂志》2016年第3期1733-1736,共4页Molecular Cardiology of China

基　　金：国家自然科学基金(课题号91539113)

摘　　要：目的探究单核苷酸多态性rs1885068不同基因型与脑卒中及其亚型患病风险的相关性。方法采用多中心病例-对照研究设计,共纳入全国7个中心1526例脑卒中患者、1561例正常对照。采用聚合酶链式反应-连接酶检测反应(PCR-LDR)技术检测病例组和对照组单核苷酸多态性rs1885068基因型。结果未发现单核苷酸多态性rs1885068基因型与脑卒中及其各亚型患病风险的显著相关性,但单核苷酸多态性rs1885068与腔隙性脑梗死(OR=1.22;95%CI:0.98-1.52;P=0.076;显性模型)和脑出血(OR=1.39;95%CI:1.00-1.93;P=0.052;隐性模型)患病风险的分析中得到边缘阳性的结果 ,T等位基因可能增加腔隙性脑梗死和脑出血的患病风险。结论单核苷酸多态性rs1885068可能与腔隙性脑梗死和脑出血的患病风险相关。Objective To investigate the association of rs1885068 with the incidence of stroke as well as its subtypes. Method Casecontrol design was conducted to investigate the association of rslgg5068 with stroke incidence. Stroke patients （n=1526） and control subjects （n=1561） from seven Chinese stroke centers were included. The genotypes of rs1885068 were analyzed by polymerase chain reactionligation-detection reaction. Results No significant association was observed between rs1885068 and incidence of stroke and the subtypes. However, marginally results were detected between rs1885068 and lacunar infarction （odds ratio=1.22; P=0.076; dominant model） and intracranial hemorrhage （odds ratio=l.39; P=0.052; recessive model）. T allele may increase the risk of lacunar infraction. Conclusions SNP rs1885068 may be associated with the incidence of lacunar infarction and intracranial hemorrhage.

关 键 词：卒中 单核苷酸多态性 患病风险 

分 类 号：R743.3[医药卫生—神经病学与精神病学]