δ-三烯生育酚抑制鼻咽癌裸鼠移植瘤生长  

Delta-tocotrienol inhibits the growth of nasopharyngeal carcinoma xenografts in nude mice

作　　者：王建红[1] 罗琴[1] 范才文[1] 李璐[1] 易世江[2] 向秋[1] 

机构地区：[1]桂林医学院科学实验中心 [2]桂林医学院附属医院

出　　处：《华夏医学》2016年第3期1-4,共4页Acta Medicinae Sinica

基　　金：国家自然科学基金资助项目(81260344);广西自然科学基金资助项目(2013GXNSFAA019228);桂林市科学研究与技术开发计划资助项目(20130120-19)

摘　　要：目的:探讨δ-三烯生育酚对鼻咽癌裸鼠移植瘤生长的影响。方法:裸鼠右前肢皮下接种鼻咽癌5-8F细胞,从接种细胞的第2天开始,每天腹腔注射δ-三烯生育酚,连续给药40 d。实验设对照组给等量溶剂(0剂量组);低剂量组(50 mg·kg^(-1)·d^(-1)δ-三烯生育酚);高剂量组(150 mg·kg^(-1)·d^(-1)δ-三烯生育酚)。结果:δ-三烯生育酚抑制鼻咽癌移植瘤生长,高剂量组移植瘤重量(0.35±0.05)g低于低剂量组(1.01±0.23)g与对照组(1.96±0.26)g,差异有统计学意义(P<0.05)。结论:δ-三烯生育酚能抑制鼻咽癌裸鼠移植瘤的生长,是一种潜在的抗鼻咽癌天然产物。Objective： To investigate the effects of delta-tocotrienol on in nude mice. Methods： Nasopharyngeal carcinoma 5-8F cells were forelimb of nude mice, from the 2nd day after cells transp nasopharyngeal carcinoma xenografts seeded subcutaneously into the fight lanting, delta-tocotrienol was daily intraperitoneally injected for 40 days. The experiment was designed 3 groups, control group was given the same amount of solvent （0 dose group）, low dose group was 50 mg· kg^-1· d^-1 deha-tocotrienol, high dose group was 150 mg· kg^-1· d^-1 delta-tocotrienol. Results： Delta-tocotrienol inhibited growth of nasopharyngeal carcinoma xenografts,the transplanted tumor weight was （0.35 ± 0.05）g in the high dose group, lower than （1.01 ± 0.23） g in the low dose group and （1.96 ±0.26）g in the control group, the differences werestatistically significant（P 〈 0.05）. Conclusion： Deha-tocotrienol can inhibit the growth of nasopharyngeal carcinoma xenografts in nude mice, and it is a potential anti-nasopharyngeal carcinoma natural product.

关 键 词：δ-三烯生育酚 鼻咽癌 裸鼠 移植瘤 

分 类 号：R739.6[医药卫生—肿瘤]