胰岛素对复治非小细胞肺癌患者化疗增效作用的临床研究  

Clinical study of the synergistic effect of insulin on chemotherapy in retreatment non-small cell long cancer patients

作　　者：邢国臣[1] 张寒梅[1] 谷见法[1] 

机构地区：[1]郑州大学附属郑州中心医院肿瘤科,河南郑州450007

出　　处：《中国医刊》2016年第7期54-56,共3页Chinese Journal of Medicine

摘　　要：目的观察胰岛素对复治非小细胞肺癌患者的化疗增效作用。方法将本院2007年10月至2010年6月50例复治非小细胞肺癌患者随机分为胰岛素增效组（26例）及对照组（24例）,胰岛素增效组于化疗前10小时应用胰岛素0.4U/kg加于10%葡萄糖注射液1000ml中静脉滴注;顺铂80mg/m2分别于第3~5天静脉滴注或第1天卡铂500mg静脉滴注,第1天及第8天长春瑞滨25mg/m2加于生理盐水100ml中静脉滴注,或第1天紫杉醇150mg/m2静脉滴注3小时,或第1天及第8天吉西他滨1000mg/m2加于生理盐水100ml中静脉滴注30分钟;对照组仅用＂长春瑞滨、顺铂或卡铂＂或＂紫杉醇、顺铂或卡铂＂或＂吉西他滨、顺铂或卡铂＂方案化疗,化疗药物用法及剂量同胰岛素增效组。21天为1个周期,两组均治疗2个周期以上。结果胰岛素增效组部分缓解13例、稳定6例、进展7例,有效率为50.0%,对照组部分缓解5例、稳定9例、进展10例,有效率为20.8%,两组有效率差异有显著性（χ2=3.920,P=0.048）。胰岛素增效组1年生存率为38.5%（10/26）,高于对照组的33.3%（8/24）,差异有显著性（χ2=3.920,P=0.048）。结论胰岛素对复治非小细胞肺癌患者化疗具有一定增效作用,可延长生存。Objective To observe the synergistic effect of insulin on chemotherapy in retreatment non-small cell long cancer patients. Method 50 cases of retreatment non-small cell long cancer patients were divided into insulin synergistic group（26 cases） and control group（24 cases）.Insulin 0.4U/kg in 10% glucose injection 1000 ml intravenous drip before chemotherapy 10 hours in insulin synergistic group, cisplatin 80mg/m2 was given by intravenous infusion divided into 3 or 5 days or carboplatin 300mg/m2 was given by intravenous infusion on 1st day, vinorelbine 250mg/m2 in 100 ml normal saline on 1st and 8th days or paclitaxel 150mg/m2 in 3h on 1st day or gemcitabine 1000mg/m2 in 100 ml normal saline in 30 minute on 1st and 8th days in two groups, 3 weeks was one cycle, each case completed with at least 2 cycles. Result The overall response rate in the insulin synergistic group was 50.0%, 13 patients achieved partial response, 6 patients stable disease, 7 patients progression disease.The overall response rate in the control group was 20.8%, 5 patients achieved partial response, 9 patients stable disease, 10 patients progression disease.There was a significant response difference checked by χ2 test between two groups（χ2=3.920, P=0.048）. 1 year survival rate was higher in insulin synergistic group（10/26, 38.5%） than in control group（8/24, 33.3%; χ2=3.920, P=0.048）. Conclusion There was certain synergistic effect of insulin on chemotherapy in retreatment non-small cell long cancer patients, and their life span was extended.

关 键 词：癌 非小细胞肺 抗肿瘤联合化疗方案 胰岛素 化疗增效 生存期 

分 类 号：R734.2[医药卫生—肿瘤]