磷酸钠盐口服溶液致低渗性脑病  

Hypotonic encephalopathy due to sodium phosphate oral solution

作　　者：韦凤华[1] 梁河[1] 

机构地区：[1]广西壮族自治区玉林市第一人民医院药学部,537000

出　　处：《药物不良反应杂志》2016年第3期225-226,共2页Adverse Drug Reactions Journal

摘　　要：1例41岁女性患者因反复便血10余年拟行肠镜检查以明确诊断，口服磷酸钠盐口服溶液（45 ml 溶于750 ml 温水）进行肠道准备，9 h 后出现恶心、呕吐、头晕、乏力、精神差、神志淡漠。急查血电解质示钾3.0 mmol/ L，钠118 mmol/ L，氯92 mmol/ L。考虑为磷酸钠盐口服溶液致电解质紊乱引起的低渗性脑病。相继给予静脉滴注10%氯化钾注射液、门冬氨酸钾镁注射液、10%氯化钠注射液、甘油果糖注射液。21 h 后患者神志转清，约27 h 后复查电解质示钾4.35 mmol/ L，钠130 mmol/ L，氯109 mmol/ L，钙2.15 mmol/ L。A 41-year-old female with repeated hematochezia for about 10 years prepared to have a colonoscopy in order to clarify a diagnosis. She took sodium phosphate oral solution（45 ml dissolved in 750 heated water） orally for bowel preparation. Nine hours later she developed the symptoms of nausea, vomiting,dizziness,weakness,and apathy. The results of laboratory test showed K ＋ 3. 0 mmol/ L,Na ＋ 118 mmol/ L,Cl- 92 mmol/ L. She was diagnosed as hypotonic encephalopathy due to electrolyte disturbances which was induced by sodium phosphate. She received IV infusion of potassium chloride injection,potassium＆amp;nbsp;aspartate and magnesium aspartatse injection,10% sodium chloride injection,and glycerol and fructose injection. Twenty-one hours later her apathy disappeared. The results of laboratory test showed K ＋ 4. 35 mmol/ L,Na ＋ 130 mmol/ L,Cl- 109 mmol/ L,Ca2 ＋ 2. 15 mmol/ L about 27 hours later.

关 键 词：水电解质失调 脑疾病 磷酸钠盐口服溶液 

分 类 号：R741[医药卫生—神经病学与精神病学]