人体粪便孵育液对酸枣仁皂苷A的代谢转化研究  

Biotransformation of Jujuboside A by Human Intestinal Flora

作　　者：庞萌萌[1] 张惠惠[1] 窦家聪 张群[1] 高鹏[1] 代龙[1] 

机构地区：[1]山东中医药大学药学院,山东济南250355

出　　处：《辽宁中医杂志》2016年第7期1459-1462,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家"重大新药创制"科技重大专项(2009ZX09103-403)

摘　　要：目的:研究酸枣仁皂苷A在人体粪便孵育液中的代谢转化。方法:人体粪便孵育液与酸枣仁皂苷A在体外37℃厌氧条件下共同培养,通过ELSD对孵育液中酸枣仁皂苷A的含量进行检测。结果:酸枣仁皂苷A与人体粪便孵育液在体外37℃厌氧条件下共同培养24 h之后,19 min处酸枣仁皂苷A峰消失,并于22 min处出现一个新峰,经ELSD检测后鉴定代谢产物为酸枣仁皂苷B。结论:酸枣仁皂苷A在人体粪便孵育液中代谢转化为酸枣仁皂苷B。Objective： To study the biotransformation of jujuboside A by human fecal incubation solution. Methods： The jujuboside A and human fecal incubation solution at 37 ℃ were incubated under anaerobic conditions to determine the content of jujuboside A of the incubation solution by ELSD. Results： The jujuboside was anaerobically incubated with human fecal incubation solution at 37 ℃ for 24 h. The chromatographic peak of jujuboside A disappeared at 19 min,a new chromatographic peak in 22 min.After the examination of ELSD,the metabolite was identified as jujuboside B. Conclusion： Jujuboside A can transform to jujuboside B in human intestinal flora in vitro.

关 键 词：人粪便孵育液 酸枣仁皂苷A 代谢转化 酸枣仁皂苷B 

分 类 号：R284[医药卫生—中药学]