盐酸多奈哌齐联合高压氧对血管性痴呆患者认知功能的影响  

Influence of donepezil hydrochloride and hyperbaric oxygen on cognitive function in patients with vascular dementia

作　　者：孟德娥[1] 郝常东[1] 

机构地区：[1]滕州市中心人民医院神经内科康复医学科,山东省滕州277500

出　　处：《中国基层医药》2016年第15期2301-2304,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨盐酸多奈哌齐联合高压氧治疗血管性痴呆对其认知功能的影响。方法选取61例血管性痴呆患者进行研究，按随机数字表法将其分为研究组（31例）和对照组（30例），对照组采用脑复康治疗，研究组采用高压氧联合盐酸多奈哌齐治疗，治疗12周后比较两组患者认知功能、日常生活能力及不良反应发生情况。结果治疗前 ADL 评分与 MMSE 评分组间比较差异无统计学意义（P ＞0．05）。治疗后研究组MMSE 评分较对照组高[（18．71±3．29）分比（15．83±3．45）分]，差异有统计学意义（t ＝3．337，P ＜0．05）。治疗后研究组 ADL 评分较对照组低[（37．12±7．13）分比（42．53±6．74）分]，差异有统计学意义（t ＝3．026， P ＜0．05）。研究组患者发生4例轻中度耳痛，1例轻度腹泻；对照组发生1例上腹部疼痛症状。两组不良反应发生率差异无统计学意义（χ2＝0．803，P ＞0．05）。治疗前后两组患者血常规及生化常规无明显变化。结论盐酸多奈哌齐联合高压氧对血管性痴呆患者认知功能改善作用显著，安全性良好。Objective To investigate the influence of donepezil hydrochloride and hyperbaric oxygen on cognitive function in patients with vascular dementia.Methods 61 cases of patients with vascular dementia were chosen to research,and were divided into research group（31 cases）and control group（30 cases）,the control group was treated with piracetam,the research group was treated with donepezil hydrochloride and hyperbaric oxygen,after 12 weeks of treatment congnitive function,daily life quality and adverse reaction between two group were compared. Results The ADL score and MMSE score between the two group had no significant difference before treatment（all P 〈0.05）.The MMSE score of the research group were higher than the control group[（18.71 ±3.29）points vs （15.83 ±3.45）points]after treatment,the difference was statistically significant （t =3.337,P 〈0.05）.The ADL score of the research group were lower than control group[（37.12 ±7.13）points vs （42.53 ±6.74）points],the difference was statistically significant （t =3.026,P 〈0.05）.4 cases of mild to moderate earache and 1 case of mild diarrhea occurred in the research group,and 1 case of upper abdominal pain occurred in the control group,there was no significant difference in the incidence of adverse reactions between the two groups （χ2 =0.803,P ＆gt;0.05 ）. Conclusion Donepezil hydrochloride combined with hyperbaric oxygen could effectively improve the cognitive function of patients with vascular dementia,and with good safety.

关 键 词：血管性痴呆 盐酸多奈哌齐 高压氧 认知功能 

分 类 号：R749.13[医药卫生—神经病学与精神病学]