动脉粥样硬化性脑梗死患者血浆氧化低密度脂蛋白与血管内皮损伤程度的关系  

The relationship between atherosclerotic cerebral infarction patients plasma oxidized low density lipoprotein and vascular endothelial injury degree

作　　者：张艳丽[1] 

机构地区：[1]菏泽市立医院神经内科,山东省菏泽274000

出　　处：《中国基层医药》2016年第15期2318-2321,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：研究脑梗死患者血浆氧化低密度脂蛋白（ox-LDL）、循环内皮细胞计数、一氧化氮（NO）水平与健康人群差异，研究检测指标相关性。方法选取50例脑梗死患者作为观察组，21例健康人群作为对照组，检测两组 ox-LDL、循环内皮细胞计数与 NO。结果观察组 ox-LDL（687±169）μg／L，循环内皮细胞计数（9．0±1．7）cells／0．9μL，NO（52．3±16．6）μmol／L，对照组上述指标分别为（350±173）μg／L、（2．5±0．5）cells／0．9μL、（77．4±21．1）μmol／L，两组比较差异均有统计学意义（t ＝5．278、8．982、4．371，均 P ＜0．05）。相关性分析显示，ox-LDL 与 NO（P ＝0．013、r ＝0．782），ox-LDL 与 CEC（P ＝0．019、r ＝0．793），CEC 与NO（P ＝0．021、r ＝0．952），均存在明显相关性。结论血管内皮损伤程度会影响到患者血浆氧化低密度脂蛋白检测结果，因此临床治疗中应重视对内皮细胞功能的保护与抗炎处理。Objective To study the difference of cerebral infarction patients plasma oxidized low density lipoprotein,circulating endothelial cells,nitric oxide levels and normal people,and study the correlation detection index.Methods 50 patients with cerebral infarction were selected as the observation group,21 cases of normal people were selected as the control group.The oxidized low density lipoprotein,circulating endothelial cells,and nitric oxide were detected.Results The plasma oxidized low density lipoprotein,circulating endothelial cells,nitric oxide levels of the observation group were （687 ±169）μg/L,（9.0 ±1.7）cells/0.9 μL,（52.3 ±16.6）μmol/L respec-tively,which of the control group were （350 ±173）μg/L,（2.5 ±0.5）cells/0.9 μL,（77.4 ±21.1）μmol/L,there were statistifically significant differences between the two groups（t =5.278,8.982,4.371,all P 〈0.05）.Correlation analysis showed that ox -LDL and NO（P =0.013,r =0.782）,ox -LDL and CEC（P =0.019,r =0.793）,CEC and NO（P =0.021,r =0.952）,there were significant correlation.Conclusion Vascular endothelial injury degree will affect the plasma oxidized low density lipoprotein in patients with test results,so the clinical treatment should pay attention to the protection and antiinflammatory treatment on the function of endothelial cells.

关 键 词：脑梗死 内皮细胞 脂蛋白类 LDL 冠状动脉疾病 

分 类 号：R743.3[医药卫生—神经病学与精神病学]