膜联蛋白A2在胃癌患者血清中的表达及意义  

The Expression and Value of Serum Annexins A2 in Patients with Gastric Carcinoma

作　　者：岑美婷[1] 张意钗[1] 黄燕文[1] 臧宁[1] 喻宁芳[1] 钟小雄[1] 

机构地区：[1]广州市第一人民医院南沙医院检验科,广东广州510045

出　　处：《贵阳医学院学报》2016年第7期837-839,共3页Journal of Guiyang Medical College

摘　　要：目的:检测膜联蛋白A2(ANXA2)在胃癌患者血清中的表达。方法:49例胃癌患者作为胃癌组,55例同期健康体检者作为对照组,采用酶联免疫吸附法检测两组被检者血清中ANXA2和肿瘤标志物CEA、AFPCA19-9及CA24-2水平,采用Pearson法分析胃癌患者血清中ANXA2水平与肿瘤标志物的相关性,采用工作曲线(ROC)分析ANXA2和3种肿瘤标志物对胃癌的诊断价值,探讨ANXA2水平与胃癌淋巴结转移的关系。结果:观察组患者血清中ANXA2、CEA及CA19-9水平均显著高于对照组(P<0.05),观察组患者血清中ANXA2水平与CEA(r=0.905,P<0.05)及CA19-9(r=0.946,P<0.05)水平均呈现显著正相关;以10.11μg/L为截点值,ANXA2诊断胃癌的敏感性为91.84%,特异性为92.73%,优于CEA及CA19-9;伴有淋巴转移胃癌患者血清中ANXA2水平显著高于无淋巴转移患者(t=2.748,P=0.009)。结论:外周血血清中ANXA2水平可作为诊断胃癌的辅助指标。Objective：To analyze the expression of serum Annexins A2（ ANXA2 ）in patients with gastric carcinoma and its auxiliary diagnostic value. Methods：Clinical data of 49 patients with gastric carcinoma as Group A,55 healthy cases as Group B. ELISA was adopted to test ANXA2,CEA and AFPCA 19-9 and CA24-2 level;adopting Pearson method to analyze correlation between ANXA 2 level and tumor marker;adopting ROC to analyze diagnostic value of ANXA2 and three tumor markers on gastric carcinoma. Results：ANXA2,CEA and CA19-9 level of Group A was obviously higher than these of Group B（P﹤0.05）. Correlation analysis showed that,for Group A patients,the levels of ANXA2 had significant positive correlation with CEA（ r=0.905 ,P﹤0.05 ）and CA19-9（ r=0.946 ,P﹤0.05）. ROC analysis showed that the ANXA2 cut-off point value of 10. 11 ug/L,as used for the di-agnosis of gastric carcinoma,provided a sensitivity of 91. 84%,a specificity of 92.73%,better than these of CEA and CA19-9. Group A patients with lymphatic metastasis had a higher level of ANXA2 than that of patients without lymphatic metastasis（ t=2.748 ,P=0.009 ）. Conclusion：The level of ANXA2 can be used as an auxiliary diagnosis marker for gastric carcinoma.

关 键 词：膜联蛋白A2 胃癌 诊断 肿瘤标记 生物学 淋巴转移 ANNEXINS A2 

分 类 号：R735.2[医药卫生—肿瘤]