垂体细胞瘤MRI表现及临床特点分析  

Magnetic resonance imaging manifestations and clinical feature analysis of pituicytoma

作　　者：崔勇[1] 马军[2] 金鹤[2] 王政[2] 全松石[1] 

机构地区：[1]延边大学附属医院放射科,133000 [2]首都医科大学附属北京天坛医院放射科,100050

出　　处：《中国医师进修杂志》2016年第7期583-586,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的：分析垂体细胞瘤的MRI影像学特征和临床特点。方法回顾性分析10例经手术和病理证实的垂体细胞瘤患者的影像学资料和临床资料。主要症状是间断性视力障碍，性功能下降1例，均行MRI检查并显示为鞍区占位。结果垂体细胞瘤的形态大多以类圆形及椭圆形为主；4例肿瘤位于鞍上，2例位于鞍内，4例位于鞍区，其中囊变1例。T1加权像（T1WI）上多呈等信号，T2加权像（T2WI）上多呈等或稍高信号。增强扫描肿瘤早期呈快速均质性强化。病理标志物：周围神经雪旺细胞特异性标记（S-100）、波纹蛋白（Vim）100%阳性，胶质纤维酸性蛋白（GFAP）、突触素（Syn）、上皮膜抗原（EMA）50%阳性。6例患者行内分泌系统检查。4例患者血清总三碘甲腺原氨酸（TT3）、血清总甲状腺素（TT4）、游离三碘甲腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（FSH）、促黄体生成素（LH）均有不同程度降低，2例患者的内分泌系统检查为正常。结论垂体细胞瘤在MRI表现上有一定的特征性。结合临床表现及内分泌系统检查，可以帮助临床定性诊断。Objective To analyze the MRI imaging feature and the clinical feature of pituicytoma. Methods The clinical data and imaging feature of 10 patients with pituicytoma who were proved histologically were retrospectively studied. Visual disturbances disorder and headache were the main complaints of all patients. One patient had sexual function decline. All patients were given the examination of MRI and showed saddle area were occupied. Results Most of pituicytoma was circular or oval morphologically. Pituicytoma located at suprasellar region in 4 patients, in the sellar in 2 patients and over the sellar region in 4 patients.In them, cystic change occured in 1 patient. In most of the cases, the tumor showed isointensity on T1WI, isointensity or slightly hyperintensity on T2WI. After injection of contrast medium, the tumor showed homogeneous enhancement in early stage. Pathological markers：S-100, and vimenlin indicated 100%positive;glial fibrillary acidic protein（GFAP）, synaptophysin （SYN） and epithelial membrane antigen（EMA） indicated 50% positive. Six patients′serum endocrine function test：the levels of serum total triiodothyronine （TT3）, total thyroxine （TT4）, free triiodothyronine （FT3）, free thyroxine （FT4）, thyroid stimulating hormone （FSH）, luteinizing hormone （LH） had different degrees of reduction in 4 patients, and these index were normal in 2 patients. Conclusions On MRI, pituicytoma has certain characteristics which might help clinical diagnosis combined with the clinical manifestation and endocrine function tests.

关 键 词：垂体肿瘤 磁共振成像 疾病特征 

分 类 号：R736.4[医药卫生—肿瘤]