丹参水溶性成分影响骨代谢的机制研究进展  

Research progress of regulatory effects of water-soluble compounds isolated form Salvia miltiorrhiza on bone metabolism

作　　者：李淑惠[1,2] 梁燕龙 杨亚军[1] 赖文秀 崔燎[1,2] 

机构地区：[1]广东医学院药理学教研室 [2]广东天然药物研究与开发重点实验室,广东湛江524023

出　　处：《中国药理学通报》2016年第7期902-905,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81273518);广东省科学计划项目(No 2012B060300027);广东医学院科技创新基金项目(No STZF101104)

摘　　要：丹参是一种治疗心血管疾病的传统中药。近年来,越来越多的研究表明,以丹参素和丹参酚酸B为代表的丹参水溶性酚酸类成分具有调节骨代谢的作用,涉及Wnt/β-catenin、ERK、BMP、OPG/RANKL/RANK以及Fox O介导的氧化应激等多种信号通路调节机制。该文主要综述丹参水溶性酚酸类成分的前述作用及分子机制,为进一步研究与开发抗骨质疏松药物提供依据。Salvia miltiorrhiza is a traditional Chinese medicine for the treatment of cardiovascular diseases .Recently, increasing evidence demonstrates that the water-soluble compounds isolated from Salvia miltiorrhiza,including tanshinol and salvianolic acid B, exert a regulatory influence on bone metabolism .The under-lying mechanism of these compounds involves various pathways , such as Wnt/β-catenin, ERK, BMP, OPG/RANKL/RANK and＆nbsp;FoxO mediated oxidative stress pathway .This paper reviews pre-vious effects and mechanism of polyphenolic acids in Salvia milt-iorrhiza , which may provide the base for the research and devel-opment of the new agents to treat osteoporosis .

关 键 词：丹参 水溶性成分 丹参素 丹参酚酸B 骨代谢 骨质疏松 

分 类 号：R-05[医药卫生] R282.71