抗肿瘤药物粒子支架在食道恶性梗阻中的应用  

Applications of Anticancer drug particles stents in malignant esophageal obstruction

作　　者：杨玉宇[1] 彭侠彪[1] 阮巍山[1] 

机构地区：[1]广东省中山市人民医院消化内科,广东中山528400

出　　处：《吉林医学》2016年第8期1885-1887,共3页Jilin Medical Journal

基　　金：2012年中山市卫生局医学科研立项课题[项目编号:J2012006]

摘　　要：目的:探讨抗肿瘤药物粒子支架在食道恶性梗阻中的应用。方法:选取90例食道恶性梗阻的患者,根据自愿原则分为三组,A组患者采用普通支架治疗,B组患者采用125I放射性粒子支架治疗,C组患者采用5-Fu化疗粒子支架治疗。术中、术后观察、统计并随访支架置入的成功率、吞咽困难缓解率、并发症发生率及1年生存期等。结果:三组患者支架置入成功率均为100%,短期吞咽困难缓解率为100%,术后再狭窄等并发症发生率三组分别为28.9%、27.1%和26.8%,差异均无统计学意义(P>0.05)。而三组患者术后平均生存期分别为(3.2±0.6)个月、(6.6±0.7)个月和(9.9±0.7)个月,差异有统计学意义(P<0.05)。结论:抗肿瘤药物粒子支架较普通支架能明显延长患者的生存期。临床应用安全、可行。Objective To investigate the anticancer drug particles stents in malignant esophageal obstruction in.Method 90 cases of malignant esophageal obstruction inpatients were selected and divided into three groups on a voluntary basis,A group of pa-tients with ordinary stents,B group treated with 125I radioactive particles stents,C group treated with 5 -Fu chemotherapy particle stents.Rate of stent success placement,dysphagia response rate,incidence of complications and 1 -year survival period were ob-served、analyzed and follow -up during operative and postoperative period.Results Success rate in three groups were 100%,short-term relief of dysphagia was 100%,postoperative complications such as restenosis rate in three groups were 28.9%,27.1% and 26.8%,respectively,the difference was not statistically significant （P 〉0.05）.The three groups of patients after an average surviv-al time was （3.2 ±0.6）months,（6.6 ±0.7）months and （9.9 ±0.7）months,respectively,the difference was statistically signifi-cant （P 〈0.05）.Conclusion Antineoplastic particle stent compared with ordinary stents could significantly prolong the survival of patients.Clinical application of safe and feasible.

关 键 词：药物粒子支架 食道恶性梗阻 应用 

分 类 号：R735[医药卫生—肿瘤]