慢性牙周炎伴2型糖尿病患者龈沟液中脂联素水平的检测及意义  

The adiponectin level in gingival crevicular fluid in patients of chronic periodontitis with diabetes mellitus type 2

作　　者：刘道洲[1,2] 吴万红[1] 姜慧[1] 张帆[3] 黄萍[1] 

机构地区：[1]口腔疾病国家重点实验室.四川大学华西口腔医学院,成都610041 [2]简阳市人民医院口腔科 [3]四川大学华西医院健康体检中心

出　　处：《实用口腔医学杂志》2016年第4期565-568,共4页Journal of Practical Stomatology

基　　金：“十一五”国家科技支撑计划(编号:2007BAIl8B02)

摘　　要：目的:探究牙周炎伴2型糖尿病患者龈沟液中脂联素水平及意义。方法:纳入慢性牙周炎伴糖尿病患者(DM&CP)、慢性牙周炎患者(CP)、健康对照者(H)各20例,记录其临床指标(SBI、PLI、PD和AL),并收集龈沟液(GCF)样本,用龈沟液测量仪periotron8000对GCF进行定量,用脂联素ELISA试剂盒检测样本中脂联素含量,比较组间检测指标的差异以及临床指标与GCF中脂联素水平的相关性。结果:DM&CP组GCF中脂联素水平显著低于其他2组(P<0.05),CP患者龈沟液脂联素水平与牙周健康组相比无统计学差异(P>0.05)。GCF中脂联素水平与临床指标PD值、AL值有负相关性(P<0.05),与SBI、PLI无明显相关(P>0.05)。结论:龈沟液中脂联素水平降低可能与DM&CP发生发展有关。Objective： To examine the adiponectin level in gingival crevicular fluid（ GCF） in patients of chronic periodontitis with diabetes mellitus type 2. Methods： 20 patients of diabetes mellitus type 2 with chronic periodontitis（ DMCP）,20 of periodontitis（ CP）and 20 health subjects（ H） were included. The periodontal indexes（ SBI,PLI,PD and AL） were measured,GCF samples were quantified by periotron 8000,the adiponectin content in GCF was tested by adiponectin ELISA kit. The relationship between the adiponectin level in GCF and the periodontal indexes of the DMCP patients was analyzed statistically. Results： The adiponectin level in GCF in group DMCP was significantly lower than that in the other 2 groups（ P〈0. 05）. The adiponectin levels in GCF in group CP and H were not statistically different. The adiponectin level in GCF was negatively correlated with PD and AL（ P〈0. 05）,but had no correlation with SBI and PLI（ P〉0. 05）. Conclusion： Decrease of adiponectin in GCF may play a role in the development of DMCP.

关 键 词：慢性牙周炎(CP) 糖尿病(DM) 龈沟液(GCF) 脂联素 

分 类 号：R781.4[医药卫生—口腔医学]