7-氮杂吲哚合成工艺改进研究  

An Improved Synthetical Route of 7-Azaindole

作　　者：高文强[1] 秦永其[1] 周喜阳[1] 

机构地区：[1]吕梁学院化学化工系,山西吕梁033000

出　　处：《精细化工中间体》2016年第3期45-47,共3页Fine Chemical Intermediates

基　　金：吕梁学院校内基金(ZRXN201501)资助

摘　　要：以2-氨基-3-甲基吡啶为原料,经过Boc保护、环化反应制备得到7-氮杂吲哚,并考察反应溶剂和碱性试剂对收率的影响。总收率为79.0%。改进后的工艺路线,操作简单,适合工业化生产。7-Azaindole was prepared from 2-amino-3-methylpyridine via amine protection and cyclization. The influence of factors on the yield of the target-product were investigated. This improved process can simplify the process in scale manipulation. The typical total yield for this process was 79.0%.

关 键 词：2-氨基-3-甲基吡啶 工艺改进 7-氮杂吲哚 

分 类 号：O626[理学—有机化学]