基质金属蛋白酶-9与结直肠癌  

Matrix metalloproteinase and colorectal cancer

作　　者：程欣[1] 黄颖[1] 刘宁[1] 

机构地区：[1]吉林大学第二医院研究中心,长春130041

出　　处：《国际肿瘤学杂志》2016年第7期538-540,共3页Journal of International Oncology

基　　金：国家自然科学基金（81472030）

摘　　要：基质金属蛋白酶（MMP）能够降解细胞外基质，对肿瘤生长、侵袭和扩散至关重要。作为MMP 家族中相对分子质量最大的，MMP-9参与结直肠癌的生成和进展。研究显示 MMP-9可用于结直肠癌患者的早期诊断，组织和血浆中 MMP-9表达水平与结直肠癌患者术后预后呈负相关。另外，针对MMP-9在结直肠癌组织中表达增加这一特点可设计相关的靶向治疗药物。Matrix metalloproteinase （MMP）plays an important role in the degradation of extracellular matrix components,which is crucial for tumor growth,invasion and metastasis.As one with the largest relative molecular mass in MMP family,MMP-9 takes part in the generation and progression of colorectal cancer. Research shows that MMP-9 can be used for the early diagnosis of colorectal cancer.The expression levels of MMP-9 in tissue and plasma are negatively correlated with prognosis of the postoperative patients with colorectal cancer.In addition,targeted therapy drugs will be designed on the basis of MMP-9 expression increased in colorectal cancer.

关 键 词：基质金属蛋白酶9 结直肠肿瘤 诊断 预后 治疗 

分 类 号：R735.34[医药卫生—肿瘤]