缺氧在多发性骨髓瘤发病机制中的作用及治疗策略  

Role and treatment strategy of hypoxia in the pathogenesis of multiple myeloma

作　　者：王维媛 郭冬梅[1] 韩天洁[1] 滕清良[1,2] 

机构地区：[1]山东省泰安市中心医院血液内科,271000 [2]泰山医学院研究生部

出　　处：《国际肿瘤学杂志》2016年第7期552-554,共3页Journal of International Oncology

基　　金：山东省自然科学基金(ZR2012HL38)；山东省医药卫生科技发展计划

摘　　要：缺氧环境在多发性骨髓瘤发病机制中起着重要作用，如促进血管生成、增加骨骼破坏、增强上皮-间充质转化和药物抵抗等。目前有多种靶向多发性骨髓瘤缺氧环境的治疗策略，如缺氧激活前体药物和分子靶向抑制剂等。针对缺氧状态的多发性骨髓瘤治疗策略是未来极具吸引力的治疗靶点之一。Hypoxia environment plays an important role in the pathogenesis of multiple myeloma such as stimulating angiogenesis,increasing bone destructiong,epithelial-mesenchymal transition and drug resis-tance.Thus,there are many therapeutic strategies targeting the hypoxic environment of multiple myeloma,such as hypoxia-activated prodrug and molecular targeting inhibitors.Targeting the hypoxic environment is a promis-ing therapy for multiple myeloma in the future.

关 键 词：缺氧诱导因子1 多发性骨髓瘤 肿瘤 代谢 

分 类 号：R733.3[医药卫生—肿瘤]