肝硬化门脉高压症的防治:新的细胞与分子靶点  

Prevention and treatment of cirrhotic portal hypertension:New cellular and molecular targets

作　　者：张妍[1] 丁惠国[1] 

机构地区：[1]首都医科大学附属北京佑安医院肝病消化中心,北京市100069

出　　处：《世界华人消化杂志》2016年第19期2950-2956,共7页World Chinese Journal of Digestology

基　　金：北京市医院管理局感染消化重点专业基金资助项目;No.ZYLX201610;北京市卫生系统高层次卫生技术人才培养计划基金资助项目;No.2011-2-19~~

摘　　要：肝窦内皮细胞一氧化氮合酶、赖氨酸氧化酶-2表达减少、新生血管形成及病理性肝窦重建是肝硬化门脉高压的病理生理新机制,黑巧克力、咖啡及绿茶可改善肝窦内皮细胞功能障碍及抑制新生血管形成,可能是延缓、逆转肝硬化门脉高压及其并发症的新方法.Cirrhotic portal hypertension results from a variety of pathological conditions including decreased expression of endothelial NO synthase and lysyl oxidase-like 2,newly formed vessels and pathological hepatic sinusoid reconstruction.Dark chocolate,coffee and green tea polyphenol can improve endothelial dysfunction and inhibit angiogenesis and thus may be new options for treating and preventing the progression of cirrhotic portal hypertension.

关 键 词：肝硬化 门脉高压症 肝窦内皮细胞 新生血管 防治 

分 类 号：R575.2[医药卫生—消化系统]