血清胃泌素17在胃肠疾病诊断中的意义  

Significance of serum gastrin 17 in diagnosis of gastrointestinal diseases

作　　者：穆亚娟[1] 冯义朝[1] 

机构地区：[1]延安大学附属医院消化内科,陕西省延安市716000

出　　处：《世界华人消化杂志》2016年第19期2996-3001,共6页World Chinese Journal of Digestology

摘　　要：血清胃泌素17(gastrin 17,G17)是由胃肠道G细胞分泌的多肽类激素,其与胆囊收缩素受体(cholecystokinin receptor,CCKR)结合后通过一系列信号转导而发挥生物学效应,主要参与刺激胃酸分泌及营养胃肠道黏膜,近年来一些研究表明血清G17还有促进增殖和抑制凋亡的作用.血清G17可以提示患者胃黏膜的功能状态,用于胃癌及癌前疾病的筛查,因此在胃肠疾病的诊断中具有重要意义.但是血清G17不仅受病变部位、萎缩程度、幽门螺杆菌(Helicobacter pylori,H.pylori)感染等胃内因素的影响,胃外因素和药物因素也是结果判定的重要影响因素.本文就血清G17的生物特性、影响因素及其与胃肠疾病的关系几个方面作一综述.Gastrin 17（G17） is a polypeptide hormone secreted by gastrointestinal G cells,and it binds to cholecystokinin receptor（CCKR） to exert its biological function through signal transduction,stimulating the secretion of gastric acid and the growth of gastrointestinal mucosa.In recent years some studies suggest that G17 promotes cell proliferation and inhibits apoptosis.Since serum G17 can provide some clues to the function of gastric mucosa and the presence of gastric cancer and precancerous disease,it is of great significance in the diagnosis of gastrointestinal diseases.However,serum G17 is affected not only by gastric factors such as the lesion,the degree of atrophy,and Helicobacter pylori（H.pylori） infection,but also by extragastric and drug factors.In this article,we discuss the biological characteristics of G17,factors influencing serum G17 and the relationship between serum G17 and gastrointestinal diseases.

关 键 词：胃泌素17 胃癌 幽门螺杆菌 萎缩性胃炎 影响因素 

分 类 号：R57[医药卫生—消化系统]