间充质干细胞的旁分泌作用及其在颅颌面骨再生治疗中的应用研究进展  

Research progress of the paracrine effects of mesenchymal stem cells and its application in the regeneration of craniomaxillofacial bone

作　　者：王贵玲[1] 仇丽鸿[1] 庞希宁[2] 

机构地区：[1]中国医科大学口腔医学院.附属口腔医院牙体牙髓病科,辽宁沈阳110002 [2]中国医科大学卫生部细胞生物学重点实验室干细胞与再生医学研究室,辽宁沈阳110122

出　　处：《中国实用口腔科杂志》2016年第6期373-378,共6页Chinese Journal of Practical Stomatology

基　　金：国家重点基础研究发展计划项目(2012CB518103);辽宁省自然科学基金项目(2014021055)

摘　　要：间充质干细胞(mesenchymal stem cells,MSCs)自被发现以来,一直在再生医学中作为理想的种子细胞,利用多向分化的潜能分化为组织细胞,以修复组织缺损。然而近年来人们发现,进入体内的MSCs增殖分化能力有限,其主要是通过旁分泌作用诱导受体自身细胞的增殖分化,从而实现局部组织的修复再生。现对MSCs的旁分泌作用及其在颅颌面骨再生治疗中的应用做一综述。Mesenchymal stem cells have been the ideal seed cells ever since being discovered,and their multiple differentiation potential is used to repair tissue defects.However,for the past few years,it has been discovered that the MSCs that have entered bodies are limited both in regeneration and differentiation;their effects on tissue regeneration is not to differentiate directly,but to induce the regeneration and differentiation of the self cells in recipient through paracrine effects.This paper mainly reviewed the paracrine effects of MSCs and their impacts on craniomaxillofacial bone regeneration.

关 键 词：间充质干细胞 旁分泌 骨再生 

分 类 号：R78[医药卫生—口腔医学]