脂联素与颅内动脉粥样硬化的关系及其可能机制  

The possible mechanism of the relationship between adiponecfin and intracranial atherosclerosis

作　　者：徐曼曼 徐运 李敬伟 

机构地区：[1]有京大学医学院附属鼓楼医院,210009

出　　处：《国际脑血管病杂志》2016年第6期561-564,共4页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金（81571134）;国家青年自然科学基金（81200896）

摘　　要：与西方人不同，颅内动脉粥样硬化（intracranial atherosclerosis, ICAS）是东方人群急性缺血性卒中的主要原因。研究表明，ICAS与代谢综合征、血脂异常、糖尿病及炎症等危险因素有关。脂联素参与氧化应激和糖脂代谢，其水平降低是代谢综合征最重要的危险因素和最显著的炎性标记物。众多研究提示，脂联素与心血管疾病有关，并将其作为一种预防标记物。近年来，脂联素与ICAS的关系成为研究热点。文章主要对脂联素在ICAS中的作用进行综述。Different from Westerners, intracranial atherosclerosis （ICAS） is a main cause for acute ischemic stroke in Eastern population. Studies have shown that ICAS is associated with the risk factors including metabolic syndrome, dyslipidemia, diabetes mellitus, and inflammation. Adiponectin is involved in oxidative stress and glycolipid metabolism, its reduced level is the most important risk factor for metabolic syndrome and the most prominent inflammatory markers. Numerous studies have suggested that adiponectin is associated with cardiovascular diseases, and it is used as a preventive marker. In recent years, the relationship between adiponectin and ICAS has become a hot research topic. This article mainly reviews the roles of adiponectin in ICAS.

关 键 词：脂联素 颅内动脉硬化 卒中 脑缺血 糖尿病 代谢综合征X 高脂血症 炎症 危险因素 生物学标记 

分 类 号：R743.3[医药卫生—神经病学与精神病学]