78例脑膜转移癌患者的预后因素分析  

Prognostic factors in 78 patients with leptomeningeal metastases

作　　者：刘洋[1] 尤振宇[1] 苏晓辉[2] 刘渤娜[1] 刘学飞[1] 

机构地区：[1]解放军第202医院肿瘤介入科,辽宁沈阳110003 [2]辽宁省肿瘤医院胃外科,辽宁沈阳110042

出　　处：《现代肿瘤医学》2016年第13期2034-2037,共4页Journal of Modern Oncology

基　　金：辽宁省科学技术计划项目(编号:2013225089)

摘　　要：目的:探讨影响脑膜转移癌(LM)患者生存的预后因素。方法:收集78例LM患者的临床资料及随访资料,分析治疗及随访的数据,并分析影响总生存期的因素。应用Cox风险模型检验性别、年龄、KPS评分、确诊时间、脑转移、其他器官转移、近期疗效、系统治疗、鞘内化疗、全脑化疗和脑脊液(CSF)细胞检测结果与患者总生存期的关系。结果:本组患者中位生存时间为62天;单因素分析显示:年龄、确诊时间、KPS评分、全身系统治疗、近期疗效、脑脊液中癌细胞变化与患者总生存期相关。多因素分析结果显示:年龄、KPS评分、近期疗效是影响患者生存的独立预后因素。结论:年龄、KPS评分、近期疗效是影响患者生存的独立预后因素。Objective：To investigate the prognostic factors for the survival in patients with leptomeningeal metasta-ses（LM）.Methods：From August 2000 to August 2013,the clinical data,follow -up results and overall survival of 78 carcinoma patients with LMwere analyzed.Cox risk model was applied to test the correlations between overall survival （OS）and the characteristics including gender,age,KPS scores,brain metastasis,other organ metastasis,response, systemic treatment,intrathecal chemotherapy,whole brain radiotherapy and cytologital test of cerebrospinal fluid （CSF）.Results：The median overall survival were for all the patients was 62 days.Single factor study showed that age,KPS score,diagnostic time,systemic treatment,response and cytologital test in cerebrospinal fluid were correlated with overall survival time for the patients.Multivariate analysis showed that age,KPS score,response were independent prognostic factors for LM.Conclusion：Age,KPS score,response were independent prognostic factors for LM.

关 键 词：脑膜转移癌 系统治疗 预后因素 

分 类 号：R739.45[医药卫生—肿瘤]