FGFR4基因多态性与Luminal型乳腺癌临床病理特征的相关性  

Association between FGFR4 gene polymorphism and clinicopathological features of Luminal breast cancer

作　　者：谢静静[1] 刘晶[2] 孙姗姗[1] 魏巍[1] 庞达[1] 姜永冬[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院乳腺外科,黑龙江哈尔滨150081 [2]哈尔滨医科大学附属第二医院麻醉科,黑龙江哈尔滨150081

出　　处：《现代肿瘤医学》2016年第13期2038-2041,共4页Journal of Modern Oncology

基　　金：国家自然科学基金青年基金(编号:81202075)

摘　　要：目的:探讨FGFR4基因多态性与Luminal型乳腺癌临床病理指标的关系,为临床个体化治疗提供理论依据。方法:采用多重单碱基延伸(Snapshot)SNP分型技术,检测415例Luminal型乳腺癌患者2个FGFR4基因多态位点。分析这些多态位点与Luminal型乳腺癌临床病理特征的关系。结果:在415例Luminal型乳腺癌中,FGFR4基因rs1966265多态频率分布:纯合野生AA型为23.4%、杂合GA型为53.7%、纯合突变GG型为22.9%;rs351855多态频率分布:纯合野生GG型为28.2%、杂合GA型为53.7%、纯合突变AA型为18.1%。两个多态位点与Luminal型乳腺癌临床分期、肿瘤大小、组织学分级、淋巴结转移无相关性(P>0.05)。结论:FGFR4基因rs1966265和rs351855位点多态性与Luminal型乳腺癌的临床病理特征之间无明显关联。Objective：To investigate the association between FGFR4 gene polymorphism and clinicopathological features of Luminal breast cancer,and to provide the theoretical basis for clinical individualized treatment.Methods：Using a multiplex single base extension（snapshot）genotyping technology,to detect 415 cases of Luminal breast canc-er patients with two FGFR4 gene polymorphism loci,and analyze the relationship between the gene polymorphism and breast cancer clinicopathological characteristic.Results：In 415 Luminal breast cancer patients,for rs1966265,the fre-quency of homozygous AA was 23.4%,the frequency of heterozygous GA homozygous GG was 53.7% and 22.9%. For rs351855,the frequency of homozygous GG was 28.2%,the frequency of heterozygous GA and homozygous AA was 53.7% and 18.1%.There was no association between the two polymorphisms and clinicopathological features in-cluding clinical stage,tumor size,histological grade and lymph node metastasis in 415 Luminal breast cancer patients （P〉0.05）.Conclusion：FGFR4 gene polymorphism was not associated with the clinicopathological features of Lu-minal breast cancer.

关 键 词：Luminal型乳腺癌 FGFR4 基因多态性 临床病理特征 

分 类 号：R737.9[医药卫生—肿瘤]