凝血指标异常与非小细胞肺癌转移及预后的关系  

Correlation between the coagulation markers and metastasis and prognosis in patients with non-small cell lung cancer

作　　者：张雪菲[1] 张帅[1] 于雁[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院呼吸肿瘤内科,黑龙江哈尔滨150000

出　　处：《现代肿瘤医学》2016年第13期2070-2072,共3页Journal of Modern Oncology

摘　　要：目的:探讨非小细胞肺癌(NSCLC)患者凝血指标异常与一般临床病理特征、转移及生存期的关系。方法:对128例NSCLC患者进行凝血指标测定,采用SPSS 17.0统计软件进行统计学处理,组间比较采用方差分析,两样本均数比较采用t检验,凝血指标与生存期关系采用线性相关分析。结果:各凝血指标与NSCLC患者的年龄、性别无相关性。腺癌组APTT值明显低于鳞癌组,D-D水平明显高于鳞癌组,PT、FIB、PLT水平与病理类型无相关性。有转移组D-D水平明显高于无转移组,APTT、PT、FIB、PLT水平与有无转移无相关性。血小板水平与生存期呈负相关(r=-0.373 9,t=3.56,P<0.01)。结论:NSCLC患者普遍存在凝血指标异常,可能与病理类型及转移有关,凝血异常可影响患者的生存期。深入研究凝血异常状态,有利于估计病情变化及判断预后,对延长患者生存期有重要意义。Objective：To investigate the relationship between coagulation markers and the clinicopathological fea-tures,metastasis and survival in patients with non -small cell lung cancer.Methods：The coagulation markers were detected in 128 patients with NSCLC,using SPSS 17.0 statistical software for analysis.Results：Each coagulation in-dex had no correlation with patient＆#39;s age or gender.Adenocarcinoma group had lower level of APTT than squamous group and had higher level of D -D than squamous group,the level of PT,FIB,PLT had no correlation with pathologi-cal types.Metastasis group had higher level of D -D than the group without metastasis.The level of APTT,PT,FIB, PLT had no correlation with metastasis.Platelet levels were negatively correlated with survival（r =-0.373 9,t =3.56,P〈0.01）.Conclusion：Coagulation disorder was common in patients with NSCLC.It may had correlation with pathological types and metastasis.Coagulation disorder can affect the survival of patients.

关 键 词：凝血指标 非小细胞肺癌 转移 预后 

分 类 号：R734.2[医药卫生—肿瘤]