AMG-1对小鼠急性戊四唑点燃癫痫的抑制作用  

Effect of AMG-1 on the Acute PTZ-kindled Siezure in Mice

作　　者：杨丽霞[1] 吕志华[1] 黄家彬[1] 张波 

机构地区：[1]荆门市第一人民医院,湖北荆门448000 [2]荆门市中医医院,湖北荆门448000

出　　处：《中医药信息》2016年第4期11-14,共4页Information on Traditional Chinese Medicine

基　　金：湖北省卫生厅科研基金资助课题(No.2007 JX3B54)

摘　　要：目的:研究AMG-1腹腔注射戊四唑(PTZ)后诱导小鼠点燃急性癫痫模型的保护效应。方法:通过PTZ促使小鼠患急性癫痫,制造癫痫模型,分别对小鼠癫痫发作强直性惊厥率的变化、潜伏期进行记录,分析AMG-1对小鼠PTZ致痫抗病的理论机制。结果:AMG-1对小鼠PTZ急性癫痫的发作级别、潜伏期、全身强直-阵挛发作持续时间等均有显著抑制作用。结论:AMG-1在PTZ诱发的小鼠急性癫痫有随剂量依赖的干扰、抑制效应。AMG-1可能作为抗癫痫的新型药物,该研究为癫痫的治疗提供了新的观点。Objective ： To study the antagonism of AMG - 1 against pentylenetetrazol （PTZ） inducing acute kin- dled seizure. Methods：Acute PTZ inducing kindled models were established in mice. Investigate the effect of AMG - 1 on PTZ kindled - sizures. Results ： AMG - 1 could significantly decrease the seizure score of PTZ in- ducing kindled seizure dose - dependently. AMG - 1 could significantly suppress the development of PTZ in- duced seizures in seizure stage, seizure latency and tonic convulsion rate. Conclusion：The results suggest that AMG- 1 has the dose- dependentantagonism against PTZ- kindled in mice.

关 键 词：AMG-1 戊四唑 癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]