结直肠癌组织中Id-1表达、临床意义及预后分析  

Expressions of Id-1,its clinical signification and prognostic analysis in colorectal adenocarcinoma tissues

作　　者：武雪亮[1] 王立坤[2] 薛军[1] 杨东东[3] 屈明[1] 郭飞[1] 杨瑞敏[2] 刘博[4] 李青[5] 

机构地区：[1]河北北方学院附属第一医院血管腺体外科,张家口075000 [2]河北北方学院附属第一医院超声医学科,张家口075000 [3]河北北方学院附属第一医院胃肠外科,张家口075000 [4]河北北方学院附属第一医院病理科,张家口075000 [5]河北北方学院第一临床医学院临床医学系,张家口075000

出　　处：《安徽医科大学学报》2016年第8期1192-1195,共4页Acta Universitatis Medicinalis Anhui

基　　金：河北省卫计委医学科学研究重点课题计划(编号:20150058);张家口市科学技术研究与发展指令计划(编号:1311055D)

摘　　要：目的研究结直肠癌组织中DNA结合分化抑制蛋白1(Id-1)蛋白表达情况及与结直肠癌患者预后的相关性。方法收集手术切除的结直肠癌和正常黏膜组织各50例,应用免疫组化SP法检测结直肠癌及正常黏膜组织中Id-1的表达,分析其与临床各病理因素的相关性;结合随访资料,应用Kaplan-Meier法和Log-rank检验分析Id-1的表达与结直肠癌患者生存的相关性;并建立Cox回归模型评估Id-1及各临床病理因素与患者预后的相关性。结果结直肠癌组织中Id-1表达阳性率为72.00%(36/50)明显高于正常黏膜组织的24.00%(12/50)(χ2=23.431,P=0.000);Id-1的表达与肿瘤浆膜浸润(χ2=4.521,P=0.034)、肿瘤TNM分期(χ2=7.044,P=0.008)、淋巴结转移(χ2=15.253,P=0.000)、肝转移(χ2=8.333,P=0.003)、脉管浸润(χ2=4.079,P=0.043)明显相关;死亡患者Id-1的表达程度为85.19%,明显高于生存患者的56.52%(χ2=5.062,P=0.025);Id-1表达水平与结直肠癌患者预后明显相关(RR=1.193,P=0.002)。结论 Id-1在结直肠癌组织中呈高表达,与结直肠腺癌的发生、侵袭有较高的相关性,且与患者生存期显著相关,是影响结直肠癌患者预后的独立危险因素。Objective To study the expression of inhibitors of DNA binding-1 （ Id-1 ） in human colorectal adenocarcinoma tissues and explore their correlation between the expression of Id-1 and clinical prognosis. Methods 50 cases of coloreetal adenocarcinoma tissues and 50 cases of normal colorectal tissues were selected. Immunohistochemistry （SP） was used to detect the expression level of Id-1 in eolorectal adenocarcinoma tissues and normal colorectal tissues, subsequently the relationship between clinical pathological features and the expression of Id-1 was analyzed. According to the follow-up data, Kaplan-Meier method and Log-rank test were employed to explore the correlation between Id-1 expression and survival rates. Cox regression analysis was performed to evaluate the con- nectionbetween Id-1 expression and prognosis. Results The positve expression level of Id-1 in eoloreetal adenocarcinoma tissues was 72. 00% （36/50）, which was obviously higher than that of normal coloreetal tissues （24.00% , 12/50） （x^2 = 23. 431 ,P = 0. 000 ）. The Id-1 expression in eolorectal adenoeareinoma tissues had significant relations with tumor invasion （ x^2 = 4. 521 ,P = 0. 034）, TNM stage （ x^2= 7. 044, P = 0. 008）, lymph node metastasis （ x^2= 15. 253, P = 0. 000 ）, liver metastasis （ x^2 = 8. 333, P = 0. 003 ）, and vessel invasion （x^2 = 4. 079, P = 0. 043 ）. Patients with higher expression of Id-1 had significantly shorter survival time （ x^2 = 5. 062, P = 0. 025 ）. The expression of Id-1 was obviously correlated with the prognosis of colorectal adenoeareinoma tissues （RR = 1. 193, P = 0. 002）. Conclusion The high expression of Id-1 in colorectal adenocarcinoma tissues plays an important role in the process of cancer, and is related to the survival time of patients with eoloreetal adenocareinoma. It is an independent prognostic factor for eolorectal adenoeareinoma.

关 键 词：ID-1 结直肠肿瘤 免疫组化 临床意义 预后分析 

分 类 号：R735.37[医药卫生—肿瘤]