APC蛋白在消化道腺瘤-癌组织中的表达及临床意义  

Expression and Clinical Significance of APC Protein in Adenoma and Adencarcinoma Tissues of Digestive Tract

作　　者：孙永刚 杜选峰 郑倩 赵倩 周围 李先平 王瑞玲 

机构地区：[1]解放军535医院消化内科,湖南怀化418000 [2]解放军第二炮兵总医院消化内科,北京100008

出　　处：《解放军医药杂志》2016年第7期37-38,50,共3页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的观察家族性腺瘤样息肉病蛋白(adenomatous polyposis col,APC)在消化道腺瘤-癌组织中的表达,探讨其在消化道肿瘤发生、发展中的作用。方法收集2012年3月—2015年3月的胃组织标本83例,包括正常胃黏膜组织25例,胃腺瘤40例(高级别上皮内瘤变18例,低级别上皮内瘤变22例),胃腺癌18例;结肠组织标本87例,包括正常结肠黏膜组织25例,结肠腺瘤42例(高级别腺瘤22例,低级别腺瘤20例),结肠腺癌20例。检测APC蛋白的表达情况。结果胃、结肠腺瘤和胃、结肠腺癌组织APC蛋白阳性表达率均分别低于正常胃、结肠黏膜组织(P<0.05);胃、结肠腺瘤组织中高级别上皮内瘤变与低级别上皮内瘤变APC蛋白阳性表达率比较差异无统计学意义(P>0.05)。结论 APC基因表达失活在消化道肿瘤的发生、发展中起重要作用,APC蛋白的检测有助于消化道早期癌的诊断。Objective To observe expression of familial adenomatous polyposis col （ APC） protein in adenoma and adencarcinoma tissues of digestive tract, and to study effect on carcinogenesis and development of digestive tract tumor. Methods A total of 83 samples of gastric tissues during March 2012 and March 2015 were collected, including 25 samples of normal gastric mucosa tissues, 40 samples of gastric adenoma （18 with high-grade and 22 with low-grade intraepithelial neoplasia） and 18 samples of gastric adenocarcinoma. A total of 87 samples of colorectal tissues were col-lected, including 25 samples of normal colorectal mucosa tissues, 42 samples of colorectal adenoma tissues （ 22 with high-grade and 20 with low-grade intraepithelial neoplasia） and 20 samples of colorectal adenocarcinoma. Expression of APC protein was detected. Results Positive expression rates of APC protein in gastric and colorectal adenoma and aden-carcinoma tissues of digestive tract were respectively lower than those in normal gastric and colorectal mucosa tissues （P〈0. 05）. There was no significant difference in positive expression rate of APC protein between the high-grade and low-grade intraepithelial neoplasia in adenoma tissues of digestive tract （ P〉0. 05 ） . Conclusion Inactivation of APC protein expression plays an important role in carcinogenesis and development of digestive tract tumor, and detection of APC protein expression may be helpful in diagnosis of early digestive tract tumor.

关 键 词：家族性腺瘤样息肉病蛋白 腺瘤 腺癌 免疫组化 

分 类 号：R735[医药卫生—肿瘤]