γ-tubulin、HER-2和k-ras在乳腺癌组织中的表达及临床意义  

Expression and Clinical Significance of γ-tubulin,HER-2 and k-ras in Breast Cancer Tissues

作　　者：张建立[1] 马金海[1] 崔伟[1] 杨永滨[2] 

机构地区：[1]保定市第二医院肿瘤外科,河北保定071051 [2]河北大学医学部病理系,河北保定071000

出　　处：《解放军医药杂志》2016年第7期47-50,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：河北省科技厅发展项目课题(102761101)

摘　　要：目的观察γ-tubulin、HER-2、k-ras在乳腺癌组织中的表达情况,探讨其临床意义。方法选择2010年1月—2014年12月手术切除的乳腺原位导管癌(DCIS)、浸润导管癌(IDC)及正常乳腺组织各60例,观察各组织中γ-tubulin、HER-2和k-ras的表达情况。结果光镜下可见γ-tubulin阳性表达于上皮细胞质中,HER-2和k-ras阳性位于细胞膜。乳腺癌组织中γ-tubulin、HER-2和k-ras阳性表达率均高于正常乳腺组织,且IDC组织中HER-2和k-ras阳性表达率高于DCIS组织(P<0.05)。结论γ-tubulin、HER-2和k-ras在乳腺组织中高表达,提示其共同参与了乳腺癌的发生发展过程。Objective To observe expressions of γ-tubulin, HER-2 and k-ras in breast cancer tissues, and to study its clinical significance. Methods Samples of 60 cases of ductal carcinoma in situ （ DCIS） tissues by surgical ab-lation were collected. The expression of K-ras, HER-2 andγ-tubulinin was observed in 60 cases of infiltrating duct carci-noma （ IDC） tissues and 60 cases of normal breast tissues during January 2010 and December 2014 were recruited in this study. Expressions ofγ-tubulin, HER-2 and k-ras were observed. Results Light microscope observation showed thatγ-tubulin was positively expressed in epithelial cytoplasm, HER-2 and K-ras were positively expressed in cell membrane. Positive expression rates of γ-tubulin, HER-2 and K-ras in breast cancer tissues were significantly higher than those in normal breast tissues, and positive expression rates of HER-2 and K-ras in IDC tissues were higher than those in DCIS tis-sues （P〈0. 05）. Conclusion High expressions ofγ-tubulin, HER-2 and K-ras in breast tissued indicates that it is in-volved in pathogenesy and development of breast cancer.

关 键 词：乳腺肿瘤 微管蛋白 基因 HER-2 基因 ras 

分 类 号：R737.9[医药卫生—肿瘤]