老年胶质瘤患者肿瘤组织中CD105和血清可溶性CD105的表达及意义  

Expression and significance of soluble CD105 in serum and CD105 in tumor tissue in patients with glioma

作　　者：田少辉[1] 许磊[1] 李盼祥 赵瑜[1] 

机构地区：[1]河北大学附属医院神经外科,河北省保定市071000

出　　处：《中国医药》2016年第8期1161-1164,共4页China Medicine

摘　　要：目的探讨老年胶质瘤患者瘤体组织中CD105及血清可溶性CD105（sCD105）的表达水平及意义。方法选取2011年5月至2014年5月于河北大学附属医院就诊的脑胶质瘤患者65例，根据病理类型分为低级别组（Ⅰ-Ⅱ级，17例）和高级别组（Ⅲ-Ⅳ级，48例）。另选同时期因脑外伤、脑出血等接受手术治疗的非胶质瘤患者40例作为对照组。对3组患者脑组织标本进行免疫组织化学染色，观察3组CD105表达差异。检测并比较3组患者血清sCD105、白细胞介素10（IL-10）、IL-6、肿瘤坏死因子仅（TNF—α）的水平。结果高级别组、低级别组CD105、sCD105、IL-10、IL-6、TNF—α表达水平均明显高于对照组[100．0％（48／48）、76．5％（13／17））比20．0％（8／40），（26．9±3．8）、（15．7±2．6）μg／L比（7．1±2．0）μg／L，（311±30）、（196±24）ng／L比（55±11）ng／L、（19．4±4．4）、（9．5±2．1）ng／L比（4．1±1．5）ng／L，（59±9）、（47±8）ng／L比（9±4）ng／L]，且高级别组表达水平明显高于低级别组，差异均有统计学意义（均P〈0．05）。胶质瘤患者血清sCD105水平与IL-10、IL-6、TNF—α水平均呈明显正相关（r=0．417、0．402、0．382，均P〈0．001）。结论老年胶质瘤患者瘤体组织中CD105及血清sCD105表达水平明显增高，且与细胞因子水平及胶质瘤分级相关。Objective To explore the expression and significance of soluble CD105 （ sCD105 ） in serum and CD105 in tumor tissues in patients with glioma. Methods Totally 65 patients with cerebral gliomas from May 2011 to May 2014 were enrolled and divided into lower-level group （Ⅰ-Ⅱ degree, 17 cases）and high-level group （Ⅲ-Ⅳ degree, 48 cases） according to the pathological type. Forty patients with non-cerebral gliomas disease were selected as control group. The immunohistochemical staining was used to measure the expression of CD105 in tumor/brain tissue ; the level of sCD105, interleukin 10 （IL-10） , IL-6, tumor necrosis factorα （TNF-α） in serum were measured and compared among three groups. Results The expression rate of CD105 in tumor/brain tissue, the levels of sCD105, IL-10, IL-6, TNF-α in serum were all significantly higher in low-level group and high-level group than those in control group [100.0% （48/48） , 76.5% （13/17） vs 20.0% （8/40）, （26.9 ±3.8） , （15.7±2.6） μg/L vs （7.1 ±2.0） μg/L, （311±30）, （196±24） ng/L vs （55±11） ng/L, （19.4±4.4）, （9.5±2.1） ng/L vs （4.1 ±1.5） ng/L, （59 ±9）, （47 ±8） ng/L vs （9±4） ng/L], and they were significantly higher than in high-level group than those in low-level group （P 〈0.05）. The level of sCD105 in serum showed significant positive correlations with IL-10, IL-6 and TNF-α （ r = 0. 417, 0. 402, 0. 382, all P 〈 0. 001 ）. Conclusion CD105 in tumor and sCD105 in serum are significantly increased in elderly patients with glioma, and are correlated with the levels of cytokines and gliomas.

关 键 词：胶质瘤 内皮蛋白CD105 可溶性CD105 细胞因子 

分 类 号：R739.4[医药卫生—肿瘤]