散发性乳腺癌中Ezrin和β-catenin蛋白表达的相关性和临床意义  

Correlation and Clinical Significance of Ezrin and β-catenin Protein Expression in Sporadic Breast Cancer

作　　者：赵琳[1] 于兆进[1] 何苗[1] 孙明立[1] 魏敏杰[1] 

机构地区：[1]中国医科大学药学院药理教研室,沈阳110122

出　　处：《中国医科大学学报》2016年第8期673-677,共5页Journal of China Medical University

基　　金：国家自然科学基金(81373427);辽宁省科学技术计划本溪生物医药产业集群项目(2014226033);辽宁省高等学校创新团队项目(LT2014016)

摘　　要：目的埃兹蛋白(Ezrin)和β-连环蛋白(β-catenin)的作用与恶性肿瘤的侵袭转移密切相关,本研究旨在探讨二者在乳腺癌中的临床意义。方法应用免疫组织化学染色法检测145例乳腺癌病理组织中Ezrin和β-catenin蛋白的表达水平,并分析二者相关性及其与乳腺癌临床资料和预后资料的相关性。结果 145例散发性乳腺癌组织中Ezrin阳性表达70例(48.3%),β-catenin阳性表达82例(56.6%),二者呈显著负相关(r=-0.267,P=0.001)。乳腺癌组织学分级增高,Ezrin表达水平显著升高(P=0.007),β-catenin表达水平显著降低(P<0.001)。发生淋巴结转移的乳腺癌组织Ezrin表达水平显著升高(P=0.027),β-catenin表达水平显著降低(P=0.011)。Ezrin蛋白表达与乳腺癌患者总体生存期(P=0.004)及无病生存期(P=0.017)缩短显著相关,β-catenin阳性表达则可显著延长患者总体生存期(P<0.001)及无病生存期(P=0.001)。但多变量Cox回归发现,Ezrin与β-catenin并非影响乳腺癌患者生存期的独立风险因素。结论乳腺癌中Ezrin和β-catenin显著负相关,且在乳腺癌转移、恶化等病程进展及不良预后过程中发挥一定作用,可作为乳腺癌治疗靶点。Objective To explore the clinical significance of Ezrin and β-catenin in breast cancer. Methods Immunohistochemical staining method was adopted to detect Ezrin and β-catenin protein expression level in 145 cases of breast cancer tissues,and their correlation with clinical data and prognosis of breast cancer was analyzed. Results Ezrin was expressed in 70 cases（48.3%）,β-catenin was expressed in 82 cases（56.6%）,and there was significantly negative correlation（r = 0.267,P = 0.001）. The higher histologic grade of breast cancer,the higher expression level of Ezrin（P = 0.007）,and the lower expression level of β-catenin（P〈0.001）. Ezrin expression level was increased significantly（P =0.027）,but β-catenin expression level was reduced significantly（P = 0.011）in lymph node positive breast cancer tissue. Ezrin expression was significantly correlated with shorter overall survival（P = 0.004）and disease free survival（P = 0.017）of breast cancer patients,but β-catenin expression was significantly correlated with longer overall survival（P〈0.001）and disease free survival（P = 0.001）of breast cancer patients. However,Ezrin and β-catenin were not the independent risk factors of breast cancer patients as determined by multivariate Cox regression. Conclusion Ezrin was significantly negative correlated with β-catenin in breast cancer. They play a role in the progression and poor prognosis of breast cancer,which can be used as breast cancer treatment targets.

关 键 词：乳腺癌 埃兹蛋白 Β-连环蛋白 转移 预后 

分 类 号：R73-3[医药卫生—肿瘤]