经肝动脉热化疗栓塞在晚期肝癌治疗中的临床应用  

Clinical Application of Thermochemoembolization Via Hepatic Artery in the Treatment of Advanced Liver Cancer

作　　者：程玉[1] 张胜[1] 饶小惠[1] 邓予[1] 罗云藩[1] 

机构地区：[1]广东省惠州市中心人民医院,广东惠州516001

出　　处：《中国医学创新》2016年第22期51-55,共5页Medical Innovation of China

基　　金：惠州市科技计划项目(2014Y122)

摘　　要：目的:探讨经肝动脉热化疗栓塞在晚期肝癌治疗中的临床应用价值。方法:选取2011年1月-2013年11月本院收治的原发性肝癌晚期患者92例作为研究对象,依据随机分配原则分为热化疗栓塞组和对照组,每组46例。对照组患者给予常规经肝动脉化疗栓塞治疗,热化疗栓塞组患者给予经肝动脉热化疗栓塞治疗(药物及碘油加热到60℃),检测分析所有患者治疗前后外周血中丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)及总胆红素(TBIL)水平变化;随访24个月,统计分析所有患者有效率和6、12、18、24个月的生存率。结果:热化疗栓塞组有效率为80.43%,明显高于对照组的58.70%,比较差异有统计学意义(P<0.05);热化疗栓塞组6、12、18、24个月的生存率均高于对照组,比较差异均有统计学意义(P<0.05);两组治疗后外周血ALT、AST及TBIL水平比较差异均无统计学意义(P>0.05)。结论:经肝动脉热化疗栓塞治疗可有效提高晚期肝癌患者的疗效,有利于延长患者的生存时间,值得临床进一步推广。Objective： To discuss the application value of thermochemoemholization via hepatic artery in the treatment of advanced liver cancer.Method ： From January 2011 to November 2013, 92 cases of advanced liver cancer in our hospital were selected as the research objects, they were divided into the thermochernoembolization group and control group according to the principle of random distribution, each group had 46 cases.The control group received standard chemoembolization therapy via hepatic artery, and thermochemoembolization group received chemoembolization with drugs heated to 60 ℃ via hepatic artery.Before and after the treatment, the levels of serum alanine aminotransferase （ ALT ）, aspartate aminotransferase （ AST ） and total bilirubin （ TBIL ） were detected and analyzed.All patients were followed up for 24 months, effective remission rate and survival rate of 6, 12, 18, 24 months were statistical analyzed.Result： Thermochemoembolization group effective remission rate was 80.43%, significantly higher than 58.70% of the control group, the differences was statistically significant （ P〈0.05 ） .The survival rate of 6, 12, 18 and 24 months in thermochemoembolization group were higher than the control group, the differences were statistically significant （ P〈0.05 ） .There were no significant differences in the levels of ALT, AST and TBIL of two groups after treatment （ P〉0.05 ） .Conclusions： Thermochemoembolization via hepatic artery can effectively improve the curative effect of patients with advanced liver cancer, and is beneficial to extend the survival time of these patients, it is worth of further clinical promotion.

关 键 词：经肝动脉热化疗栓塞 化疗栓塞 晚期肝癌 生存率 

分 类 号：R735.7[医药卫生—肿瘤]