卵巢上皮性癌雌激素受体、孕激素受体的表达及与其预后的关系  

Expressions of Estrogen and Progesterone Receptors and its Prognosis Value in epithelial ovarian cancer

作　　者：韩丽丽[1] 王华杰[1] 张慧慧[1] 付莉[1] 

机构地区：[1]吉林大学第二医院妇产科,吉林长春130041

出　　处：《中国实验诊断学》2016年第7期1106-1108,共3页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省卫计委课题(2015Z033)

摘　　要：目的研究雌激素受体(ER)、孕激素受体(PR)在卵巢上皮性癌中的表达情况,探讨其在卵巢癌发生中的作用以及与患者预后的关系。方法对68例卵巢上皮性癌组织、35例良性上皮肿瘤组织及10例正常卵巢组织采用免疫组化法测定其ER、PR表达情况,电话随访卵巢上皮性癌组3年复发情况,采用SPSS软件进行统计学分析。结果在研究的68例卵巢癌患者中,ER阳性者例数有43(63.24%),PR阳性者例数有45(66.18%),恶性组的两检测指标明显高于正常对照组、良性组,P<0.05。ER、PR的阳性表达在卵巢上皮性癌各项临床病理特性的对比中,没有明显的统计学差异(P>0.05)。结论本次研究实验结果表明,ER、PR阳性率在卵巢上皮性癌中明显增高,但与其临床病理类型、分期及分级没有明显关系。Objective This paper was to evalute the expression level of Estrogen receptor（ER）and Progesterone receptor（PR）in epithelial ovarian cancer（EOC）and their relationship with the prognosis of EOC patients.Methods the ER and PR expression level in ovarian tissue were determined by immunohistochemical method in 68 ECO patients,35 ovarian benign tumor patients and 10 control healthy individuals.Follow-up recurrence of ovarian epithelial carcinoma group three years by telephone.Using the SPSS software for the statistical analysis.Results The expression of ER positive cases for 43（63.24%）and PR positive cases for 45（66.18%）in 68 cases of EOC.Two detection indexes in the EOC tissue group was obviously higher than that of benign epithelial tumor group and normal ovarian tissue in the control group,P〈0.05.The ER and PR positive expression in ovarian epithelial carcinomathe clinical pathological features of comparison,there is no significant difference of statistical significance（P〈0.05%）.Conclusion The experimental results show that by this study,the positive expression rates of ER and PR increase obviously in EOC,but they have no obvious relations with the clinical pathological type and staging and stage of ovarian cancer.

关 键 词：孕激素受体 雌激素受体 免疫组化 预后 卵巢癌 

分 类 号：R737.31[医药卫生—肿瘤]