热休克蛋白27,60和90在胃癌中表达及其临床价值  

Expression of heat shock protein 27,60 and 90 in gastric cancer and its clinical value

作　　者：张占东[1] 杨巍[1] 马飞[1] 张永磊[1] 马二民[2] 孔烨[1] 刘洪兴[1] 花亚伟[1] 

机构地区：[1]郑州大学附属肿瘤医院河南省肿瘤医院普外科,郑州450008 [2]郑州人民医院肿瘤外科,郑州450000

出　　处：《中国免疫学杂志》2016年第7期1042-1049,共8页Chinese Journal of Immunology

摘　　要：目的:探讨HSP-27、-60和-90在胃癌中的表达及其临床意义。方法:采用免疫组织化学检测66例胃癌组织中HSP-27、-60和-90的表达情况,并结合临床病理特征、肿瘤增殖能力和患者生存期分析三种热休克蛋白表达的临床意义。结果:HSP-27、-60和-90在胃癌组织中异常高表达。HSP-27表达与肿瘤大小(p T,P=0.026)、器官转移(p M,P=0.046)及病理分期(P=0.041)相关,而HSP-27染色强度与淋巴腺状态明显相关(p N,P=0.042)。HSP-60表达与患者性别相关(P=0.011),而HSP-60染色强度与患者年龄(P=0.027)和肿瘤病理组织学分级(P=0.031)相关。HSP-90表达与本研究分析的临床病理参数无相关性;但是,HSP-90染色强度与肿瘤大小存在着显著关系(p T,P=0.020)。单因素分析表明HSP-90高表达与生存期更长显著相关(P=0.033),多因素分析证实HSP-90高表达是胃癌独立预后因素(P=0.026)。结论:HSP-27、-60和-90与某些临床病理参数有关,这些参数对于胃腺癌患者的治疗至关重要。胃腺癌患者HSP-90高表达是独立预后指标。Objective： To investigate the expression of HSP-27,-60 and-90 in gastric cancer and its clinical significance. Methods： 66 cases of gastric carcinoma was detected by immunohistochemistry HSP-27,60 and 90 of the expression and clinical significance of combined with clinical and pathological characteristics,tumor cell proliferation and survival analysis of three kinds of heat shock protein expression. Results： HSP-27,-60 and-90 were highly expressed in gastric cancer tissues. HSP-27 expression and tumor size（ p T,P = 0. 026）,organ metastasis（ p M,P = 0. 046） and pathological staging（ P = 0. 041）,HSP-27 staining intensity and lymph node status were significantly correlated（ p N,P = 0. 042）. HSP-60 expression was associated with gender（ P = 0. 011）,and HSP-60 staining intensity was associated with age（ P = 0. 027） and tumor grade（ P = 0. 031）. There was no correlation between HSP-90 expression and the clinical pathological parameters of this study; however,the intensity of HSP-90 staining was significantly correlated with tumor size（ P = 0. 020,p T）. Single factor analysis showed that HSP-90 was significantly associated with longer survival（ P = 0. 033）. Multivariate analysis demonstrated that HSP-90 was highly expressed as an independent prognostic factor for gastric cancer（ P = 0. 026）. Conclusion： the HSP-27,-60 and-90 and some clinical pathological parameters. These parameters is very important for the treatment of patients with gastric cancer. The high expression of HSP-90 in patients with gastric cancer were independent prognostic indicators.

关 键 词：热休克蛋白27 热休克蛋白60 热休克蛋白90 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]