神经元去极化反跳现象的研究进展  

Research progress in rebound depolarization of neurons

作　　者：李凌超[1] 朱梦叶 张达颖[1] 柳涛[2] 

机构地区：[1]南昌大学第一附属医院疼痛科,江西南昌330006 [2]南昌大学第一附属医院儿科,江西南昌330006

出　　处：《中国病理生理杂志》2016年第7期1331-1335,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81560198;No.81260175);南昌大学研究生创新基金资助项目(No.cx2015166)

摘　　要：神经元受刺激后产生动作电位,并将该刺激信号传递给其它的神经元,进而影响整个神经回路。这种接受去极化刺激后能够产生动作电位的特性,是判断细胞是否具有兴奋性的标准。然而亦有研究表明,Rebound depolarization is a special phenomenon of the neurons which generates action potential followed by a hyperpolarization stimulation. It can be recorded in many kinds of neurons and is the intrinsic membrane characteristic of them. Rebound depolarization plays an important role in regulating the firing pattern,rhythmic activity and synaptic plasticity of neurons. This review focuses on the basic characteristics,the function and mechanism of the rebound depolarization in physiological and pathological conditions,which provides reference for the clinical treatment of rebound depolarization-related diseases.

关 键 词：去极化反跳 超极化 神经元 动作电位 

分 类 号：R363[医药卫生—病理学]