乳腺癌微血管生长与中医辨证分型的相关性探讨  

Correlation Between Microvessel Growth And Differentiation of Traditional Chinese Medicine In Breast Cancer

作　　者：朴明姬[1] 

机构地区：[1]辽宁中医药大学附属医院外一科,沈阳110032

出　　处：《中国中医基础医学杂志》2016年第7期927-928,共2页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的:探讨乳腺癌微血管生长与中医辨证分型的相关性。方法:随机选取本院2013年1月至2014年12月间90例乳腺癌患者为研究对象,依据中医辨证分型将其分为3型,并测定不同分型患者的血管内皮生长因子(vascular endothelial growth factor,VEGF)和碱性成纤维生长因子(fibroblast growth factor,b FGF)以及微血管密度值(microvessel density,MVD)。结果:VEGF、b FGF阳性表达多见于乳腺癌痰瘀互结型患者,其次为冲任失调和肝郁气滞型患者。不同中医分型中VEGF、b FGF阳性表达率比较差异有统计学意义,痰瘀互结型、冲任失调型和肝郁气滞型患者的MVD值比较差异有统计学意义,且痰瘀互结型患者MVD值明显高于冲任失调型和肝郁气滞型。结论:临床中乳腺癌微血管生长与中医辨证分型具有一定的联系,VEGF、b FGF和MVD值可作为乳腺癌中医分型的重要指标。Objective： To investigate the correlation of the growth of breast cancer microvascular and syndrome differentiation type. Methods： Select 90 cases of breast cancer patients between January 2013 to December 2014 for the study,based on traditional Chinese medicine syndrome differentiation,the patients will be divided into three types,and measured vascular endothelial growth factor in patients（ vascular endothelial growth factor,VEGF） and basic fibroblast growth factor（ fibroblast growth factor,b FGF） and microvessel density（ microvessel density,MVD） value. Results：VEGF,b FGF expression are most commonly in breast cancer patients with phlegm,followed by Chong and Ren disorders and in patients with liver Qi stagnation. VEGF,b FGF positive expression rate difference was statistically significant of different TCM type. Phlegm type,MVD value difference Chong and Ren disorders and liver Qi stagnation type of patients was statistically significant. And phlegm type MVD values were significantly higher than those of Chong and Ren disorder type and qi stagnation type. Conclusion： The clinical breast cancer microvessel growth and TCM Typing has a certain contact. VEGF, b FGF and MVD values can be used as an important indicator of breast cancer TCM Syndreme differentiation.

关 键 词：乳腺癌 微血管生长 中医分型 相关性 

分 类 号：R737.9[医药卫生—肿瘤]