^(125)I粒子植入治疗腹膜后淋巴结转移癌分析  

Analyses of ^(125)I particles implantation in the treatment of retroperitoneal lymph node metastasis cancers

作　　者：戴文燕 钟桂强 周爱娇 王军兰 潘新 

机构地区：[1]广州现代医院肿瘤科,广州510500

出　　处：《中国当代医药》2016年第20期84-86,共3页China Modern Medicine

摘　　要：目的探讨^(125)I粒子植入治疗腹膜后淋巴结转移癌的临床疗效。方法选取2011年7月~2015年4月我科收治的54例腹膜后淋巴结转移癌患者为研究对象,在CT引导下经皮穿刺腹膜后淋巴结转移癌行^(125)I粒子植入,植入粒子数目根据病变大小而定(10~100粒),观察肿瘤局部控制率及疼痛控制情况并进行分析。结果 54例患者中有41例疼痛的患者,1个月后疼痛缓解率为92.7%。腹膜后转移瘤局部疗效评价,2个月后ORR 94.4%,4个月后ORR 94.4%。随访4~54个月,中位PFS 10.7个月。结论 ^(125)I粒子植入治疗腹膜后淋巴结转移癌可显著减轻疼痛症状,控制局部肿瘤的进展,是一种安全有效的微创治疗。Objective To investigate the clinical effectiveness of ^125I particles implantation in the treatment of retroperitoneal lymph node metastasis cancers.Methods Altogether 54 patients with retroperitoneal lymph node metastasis cancers treated in our department of oneology from July 2011 to April 2015 were selected research study.CT-guided percutaneous puncture and iodine-125 particles implantation were performed for retroperitoneal lymph node metastasis cancers patients,the number of implanted particles varied according to the size of lesions （10-100 particles） and underwent iodine-125 particles implantation in retroperitoneal metastasis lymph nodes cancers.The tumor local control rate and pain control were observed and analyzed.Results Among 54 cases of retroperitoneal lymph node metastasis cancers, 41 patients suffered from pain and remission rate of pain control after 1 month was 92.7%.Evaluation of local curative effects for retroperitoneal metastasis eancers：ORR after 2 months was 94.4%,with 94.4% ＂after 4 months.Followed-up for 4-54 months,median PFS （progression-free survival） was 10.7 months.Conclusion ^125I particles implantation in the treatment of retroperitoneal lymph node metastasis cancers serves as a safe and effective minimally invasive treatment, which can significantly reduce the pain symptoms and control the progress of local tumors.

关 键 词：腹膜后淋巴结转移癌 ^125I粒子 疼痛 

分 类 号：R735.4[医药卫生—肿瘤]