GRP78和KIAA1324在胃癌中的表达及与预后的关系  

Expression of GRP78 and KIAA1324 proteins in gastric cancer and their prognostic value

作　　者：胡永伟[1] 韩玮[1] 朱荣[1] 曹方[1] 丁厚中[1] 

机构地区：[1]江苏大学附属昆山医院普外科,江苏昆山215300

出　　处：《临床肿瘤学杂志》2016年第7期609-612,共4页Chinese Clinical Oncology

摘　　要：目的 探讨GRP78和KIAA1324蛋白在胃癌组织中的表达及其与预后生存的关系。方法 采用免疫组织化学法检测90例胃癌组织中GRP78和KIAA1324蛋白的表达,分析两者的表达与胃癌临床病理特征的关系。Kaplan-Meier法计算患者生存率,并行Log-rank检验。结果 胃癌组织中GRP78和KIAA1324蛋白的阳性表达率分别为78.89%（71/90）和35.56%（32/90）。GRP78和KIAA1324蛋白表达与淋巴结转移、TNM分期有关（P〈0.05）,而与年龄、性别、肿瘤大小和组织学分级无关（P〉0.05）。GRP78与KIAA1324蛋白表达呈负相关（r=-0.469,P〈0.05）。GRP78阳性患者的中位生存期为49.78个月（95%CI：44.09-55.46个月）,较阴性患者的62.21个月（95%CI：53.29-71.14个月）短,差异有统计学意义（P〈0.05）;KIAA1324阳性患者的中位生存期为60.66个月（95%CI：53.63-67.69个月）,较阴性患者的47.85个月（95%CI：41.46-54.23个月）长,差异有统计学意义（P〈0.05）。结论 GRP78和KIAA1324蛋白在胃癌发生、发展中发挥重要作用,可能成为判断胃癌预后的指标。Objective To investigate the expression of GRP78 and KIAA1324 proteins in gastric cancer and their correlation with clinicopathological parameters and prognosis. Methods Immunohistochemical technique was used to detect the expression of GRP78 and KIAA1324 proteins in 90 cases of gastric cancer tissues. The relationship between the expression of GRP78 and KIAA1324 proteins and clinicopathological parameters was analyzed. The survival rate was calculated by Kaplan-Meier method. The survival differ-ences were analyzed by Log-rank test. Results The positive rates of GRP78 and KIAA1324 were 78. 89%（71/90） and 35. 56%（32/90） , respectively. The expression of GRP78 and KIAA1324 was correlated with lymph node metastasis and TNM stage （ P〈0. 05） . The expression of GRP78 was negatively related to expression of KIAA1324（r=-0. 469,P〈0. 05）.The median survival time of patients with positive expression of GRP78 was 49. 78 months（95%CI：44. 09-55. 46）,which was lower than 62. 21 months（95%CI：53. 29-71. 14） of patients with negative expression of GRP78,with significant difference（ P〈0. 05） . The median survival time of patients with positive expression of KIAA1324 was 60. 66 months（ 95%CI：53. 63-67. 69） , which was higher than 47. 85 months（ 95%CI：41. 46-54. 23） of patients with negative expression of KIAA1324, with significant difference（P〈0. 05）. Conclusion GRP78 and KIAA1324 play im-portant roles in generation and development of tumor, and they may serve as promising targets for therapy of gastric cancer.

关 键 词：GRP78 KIAA1324 免疫组织化学 胃癌 预后 

分 类 号：R735.2[医药卫生—肿瘤]