肿瘤浸润淋巴细胞在三阴性乳腺癌中作用的研究进展  

Research progress of tumor-infiltrating lymphocytes in triple-negative breast cancer

作　　者：方和慧 杨芳[1] 管晓翔[1] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院肿瘤内科,南京210002

出　　处：《临床肿瘤学杂志》2016年第7期650-653,共4页Chinese Clinical Oncology

基　　金：江苏省临床科技专项(BL2014071)

摘　　要：三阴性乳腺癌(TNBC)是一种高度异质性的疾病。因缺乏有效的治疗靶标,故临床预后较差。尽管大量文献报道肿瘤浸润淋巴细胞与TNBC预后之间的关系,但区分不同类型的T淋巴细胞极其重要,因为他们在肿瘤微环境中发挥着不同的作用。此外,有研究发现肿瘤相关巨噬细胞与TNBC预后不良相关。本文将对不同淋巴细胞浸润在TNBC临床预后中的作用作一综述。Triple-negative breast cancer（ TNBC） is a heterogeneous disease. It is often characterized by the lack of specific therapeutic molecular targets and poor prognosis. There are increasing evidences about the relationship between tumor-infiltrating lym-phocytes and the prognosis of TNBC. However, the distinction between different types of T lymphocytes is extremely important, because of their different roles in the tumor microenvironment. Moreover, tumor-associated macrophages have been associated with a relatively poor outcome in TNBC. In this article, we review the role of different lymphocyte infiltration in the clinical outcome of TNBC.

关 键 词：肿瘤浸润淋巴细胞 三阴性乳腺癌 肿瘤相关巨噬细胞 预后 

分 类 号：R737.9[医药卫生—肿瘤]