吉西他滨辅助化疗对乳腺癌术后患者COX-2、CA15-3和CEA的影响  

Effect of gemcitabine adjuvant chemotherapy on serum COX-2,CA15-3 and CEA levels in postoperative breast cancer patients

作　　者：郑亚兵[1] 邵喜英[1] 石磊[1] 黄平[1] 黄圆[1] 

机构地区：[1]浙江省肿瘤医院乳腺肿瘤内科,浙江杭州310006

出　　处：《中国生化药物杂志》2016年第5期57-59,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：浙江省医药卫生基金(2013KYB050)

摘　　要：目的探讨吉西他滨辅助化疗对乳腺癌术后患者血清中环氧化酶-2、CA15-3和CEA水平影响。方法选取浙江省肿瘤医院肿瘤内科收治的乳腺癌术后患者76例,按治疗方法不同进行分组,对照组38例术后予以CMF方案(环磷酰胺+甲氨蝶呤+5-氟尿嘧啶,CTX+MTX+5-FU),研究组38例予以GP方案(吉西他滨+顺铂)治疗,治疗前及治疗3周期后测定血清环氧化酶-2(COX-2)、癌抗原15-3(CA15-3)及癌胚抗原(CEA)水平,评定生存质量状况,同时对比临床疗效、不良反应及远期效果。结果研究组有效率81.58%高于对照组有效率60.53%,差异具有统计学意义(P<0.05);与对照组比较,研究组治疗后躯体功能、角色功能、社会功能及情绪功能评分增高,研究组治疗后COX-2、CA15-3及CEA显著降低,研究组白细胞下降及手足综合征的不良反应率低,差异具有统计学意义(P<0.05);2组间转移率和局部复发率差异无统计学意义。结论采用吉西他滨乳腺癌术后辅助化疗近期疗效满意,提高患者生存质量,不良反应可耐受。Objective To investigate the effects of serum cyclooxygenase - 2 （COX-2）, CA15-3 and CEA levels by gemcitabine adjuvant chemotherapy in patients with postoperative breast cancer. Methods A total of 76 patients with breast cancer postoperative in department of breast tumour medicine from our hospital were collected, according to the different methods were divided into experimental group and control group with 38 cases in each group. Patients in the control group were treated by CMF scheme （ CTX ＋ MTX ＋ 5-FU ）, patients in the experimental group were treated by GP scheme（ gemcitabine ＋ cisplatin）, the COX-2, CA15-3 and CEA levels before treatment and after 3 cycles treatment were determined, the quality of life was evaluated, and the clinical efficacy, adverse reactions and long-term effects were compared. Results The effective rate of the experimental group （81.58%） was higher than the control group （60. 53% ）, with satistical significance （P 〈 0. 05 ）; compared with the control group, the physical function, role function, social function and emotional function scores of the experimental group were increased after treatment, the COX-2, CA15-3 and CEA levels of the experimental group were significantly decreased after treatment, the white blood cells decline, hand-foot syndrome adverse reactions rate of the experimental group were lower, with statistical significance （P 〈 0. 05 ） ; the transfer rate and local recurrence rate of the two groups had no difference. Conclusion The postoperative short-term curative effect of gemcitabine in the adjuvant chemotherapy treatment of patients with breast cancer is satisfying, could improve the quality hfe of patients, and the adverse reactions could be tolerated.

关 键 词：吉西他滨 辅助化疗 乳腺癌术后 COX-2 CA15-3 CEA 

分 类 号：R737.9[医药卫生—肿瘤]