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作 者:操跃 杨喜晶[2] 周福平[2] 张迁[2] 钱其军[2]
机构地区:[1]福建医科大学第一临床医学院,福建福州350108 [2]第二军医大学附属东方肝胆外科医院生物治疗科,上海200438
出 处:《药学实践杂志》2016年第4期366-371,共6页Journal of Pharmaceutical Practice
基 金:上海市卫生局重点项目(20134018)
摘 要:目的探讨树突状细胞-细胞因子诱导的杀伤细胞(dendritic cell-cytokine-induced killers,DC-CIK)治疗与结直肠癌患者预后的关系,以便更好地为临床治疗提供参考。方法回顾性分析东方肝胆外科医院生物治疗科2012年1月至2014年1月收治的66例结直肠癌患者信息,随访。在以性别、年龄、病理分化程度、TNM分期、接受手术的方式及是否接受靶向治疗为研究基础上,通过Kaplan-Meier单因素和Cox多因素分析,重点探讨DC-CIK治疗对患者预后的影响。结果 Kaplan-Meier单因素分析结果提示:接受DC-CIK治疗在一定程度上能改善患者的预后;Cox多因素分析结果提示:是否接受DC-CIK治疗是影响患者预后的独立因素。结论接受DC-CIK治疗可改善结直肠癌患者的预后。Objective To discuss dendritic cell-cytokine-induced killer(DC-CIK)cell therapy effects and clinical outcomes in patients with colorectal cancer in order to have better clinical treatment.Methods A retrospective analysis of the data of 66 patients with colorectal cancer from the Biological Therapy Department of the Eastern Hepatobiliary Surgery Hospital was performed from January 2012 to January 2014,and then was followed up.Taking gender,age,degree of pathological differentiation,TNM staging,surgical methods,and targeted therapy as the research basis,by the Kaplan-Meier single factor and Cox multiple factors analysis we mainly discuss the DC-CIK cell treatment′s effect on the prognoses of patients.Results KaplanMeier single factor analysis results indicate:to a certain extent,DC-CIK cell therapy can improve the prognoses of patients;Cox multi-factor analysis results indicate whether accepting DC-CIK cell therapy is an independent factor influencing the prognoses of patients.Conclusion DC-CIK cells therapy can improve the prognoses of patients with colorectal cancer.
关 键 词:结直肠癌 预后 树突状细胞-细胞因子诱导的杀伤细胞 药物靶向治疗
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