A new brain stimulation method: Noninvasive transcranial magneto–acoustical stimulation  

作　　者：袁毅 陈玉东 李小俚 

机构地区：[1]Institute of Electrical Engineering, Yanshan University [2]State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research,Beijing Normal University [3]Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University

出　　处：《Chinese Physics B》2016年第8期222-227,共6页中国物理B（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.61503321 and 61273063);the Natural Science Foundation of Hebei Province,China(Grant No.F2014203161)

摘　　要：We investigate transcranial magneto–acoustical stimulation（TMAS） for noninvasive brain neuromodulation in vivo.TMAS as a novel technique uses an ultrasound wave to induce an electric current in the brain tissue in the static magnetic field. It has the advantage of high spatial resolution and penetration depth. The mechanism of TMAS onto a neuron is analyzed by combining the TMAS principle and Hodgkin–Huxley neuron model. The anesthetized rats are stimulated by TMAS, resulting in the local field potentials which are recorded and analyzed. The simulation results show that TMAS can induce neuronal action potential. The experimental results indicate that TMAS can not only increase the amplitude of local field potentials but also enhance the effect of focused ultrasound stimulation on the neuromodulation. In summary, TMAS can accomplish brain neuromodulation, suggesting a potentially powerful noninvasive stimulation method to interfere with brain rhythms for diagnostic and therapeutic purposes.We investigate transcranial magneto–acoustical stimulation（TMAS） for noninvasive brain neuromodulation in vivo.TMAS as a novel technique uses an ultrasound wave to induce an electric current in the brain tissue in the static magnetic field. It has the advantage of high spatial resolution and penetration depth. The mechanism of TMAS onto a neuron is analyzed by combining the TMAS principle and Hodgkin–Huxley neuron model. The anesthetized rats are stimulated by TMAS, resulting in the local field potentials which are recorded and analyzed. The simulation results show that TMAS can induce neuronal action potential. The experimental results indicate that TMAS can not only increase the amplitude of local field potentials but also enhance the effect of focused ultrasound stimulation on the neuromodulation. In summary, TMAS can accomplish brain neuromodulation, suggesting a potentially powerful noninvasive stimulation method to interfere with brain rhythms for diagnostic and therapeutic purposes.

关 键 词：transcranial magneto-acoustical stimulation brain neuromodulation electric current Hodgkin-Huxley neuron model 

分 类 号：R741.04[医药卫生—神经病学与精神病学]