Routine Hemostasis and Hemogram Parameters： Valuable Assessments for Coagulation Disorder and Chemotherapy in Cancer Patients  

作　　者：Ying-Wei Zhu Tong-Bao Feng Xian-Ju Zhou Xue-Li Hu Jie Ding Wen-Yu Zhu Dan-Ping Qian Yi-Wu Sun 

机构地区：[1]Department of Oncology, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China [2]Oncology Institute, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China [3]Neurologic Disease Research Laboratory, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China [4]Department of Hematology, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China

出　　处：《Chinese Medical Journal》2016年第15期1772-1777,共6页中华医学杂志（英文版）

摘　　要：Background： The clotting system abnormalities are the common complication in cancer patients. The aim of this retrospective study was to evaluate the coagulation state, clinical features, and treatment in cancer patients by routine tests. Methods： A total of 2328 patients with different types of cancer were classified as the positive group （n = 1419, including 53 patients with thrombosis） and the negative group （n = 909） based on D-dimer （DD） value. Of the 2328 cases, 354 were admitted for chemotherapy. Hemostasis test and complete blood count （CBC） were perfbrmed during treatment or following-up. Results： This study showed that the hypercoagulable state was affected not only by clinical staging （P 〈 0,0001） but also by metastasis site （P 〈 0.0001 for bone vs. lung）. Compared to negative DD group, the higher fibrinogen level, the extended activated partial thromboplastin time, and prothrombin time interacted markedly with disease clinical stage （P 〈 0.05） in the positive group. Between positive DD groups with and without thrombus, the significantly statistic difference in white blood cell （WBC） and DD （P 〈 0.05） rather than in red blood cell （RBC） and platelet count was observed. However, the higher DD level was not correlated with WBC, RBC, and platelet count in the positive DD group. Furthermore, the hypercoagulable plasma profile in cancer patients was moderated 2-3 weeks alter chemotherapy （P 〈 0.05 for first six cycles）. Conclusions： The routine hemostatic parameters and CBC are valuable to assessment for thrombosis and chemotherapy even for disease prognosis.Background： The clotting system abnormalities are the common complication in cancer patients. The aim of this retrospective study was to evaluate the coagulation state, clinical features, and treatment in cancer patients by routine tests. Methods： A total of 2328 patients with different types of cancer were classified as the positive group （n = 1419, including 53 patients with thrombosis） and the negative group （n = 909） based on D-dimer （DD） value. Of the 2328 cases, 354 were admitted for chemotherapy. Hemostasis test and complete blood count （CBC） were perfbrmed during treatment or following-up. Results： This study showed that the hypercoagulable state was affected not only by clinical staging （P 〈 0,0001） but also by metastasis site （P 〈 0.0001 for bone vs. lung）. Compared to negative DD group, the higher fibrinogen level, the extended activated partial thromboplastin time, and prothrombin time interacted markedly with disease clinical stage （P 〈 0.05） in the positive group. Between positive DD groups with and without thrombus, the significantly statistic difference in white blood cell （WBC） and DD （P 〈 0.05） rather than in red blood cell （RBC） and platelet count was observed. However, the higher DD level was not correlated with WBC, RBC, and platelet count in the positive DD group. Furthermore, the hypercoagulable plasma profile in cancer patients was moderated 2-3 weeks alter chemotherapy （P 〈 0.05 for first six cycles）. Conclusions： The routine hemostatic parameters and CBC are valuable to assessment for thrombosis and chemotherapy even for disease prognosis.

关 键 词：CANCER CHEMOTHERAPY Coagulation Disorder THROMBOSIS 

分 类 号：S816.73[农业科学—饲料科学] Q51[农业科学—畜牧学]