Aerobic Alcohol Ammoxidation Catalyzed by Copper（I）/Amino Acid： a Scalable Protocol to Nitriles  

作　　者：ZHANG Guofu ZHANG Guihua LEI Jie LI Shasha XU Shengjun DING Chengrong SHAN Shang 

机构地区：[1]College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China

出　　处：《Chemical Research in Chinese Universities》2016年第4期586-593,共8页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（No.20702051） and the Natural Science Foundation of Zhejiang Province, China（No.LY 13B020017）.

摘　　要：A facile, practical and scalable catalyst system for alcohols ammoxidation into nitriles was developed using amino acid as ligand, oxygen as terminal oxidant and copper iodide（CuI） as catalyst. The catalyst system shows excellent functional groups compatibility for a wide range of testing substrates, even the substrates bearing oxidationsensitive groups such as MeS-, alkenyl and --NH2 can also work well. In addition, the protocol is readily scaled up to more than 20 g and the product can be obtained just through filtration or distillation without conventional column chromatography.A facile, practical and scalable catalyst system for alcohols ammoxidation into nitriles was developed using amino acid as ligand, oxygen as terminal oxidant and copper iodide（CuI） as catalyst. The catalyst system shows excellent functional groups compatibility for a wide range of testing substrates, even the substrates bearing oxidationsensitive groups such as MeS-, alkenyl and --NH2 can also work well. In addition, the protocol is readily scaled up to more than 20 g and the product can be obtained just through filtration or distillation without conventional column chromatography.

关 键 词：ALCOHOL Amino acid NITRILE Copper iodide Scale up 

分 类 号：TQ032[化学工程] Q517[生物学—生物化学]