Design and Synthesis of 1,4-Dihydropyridine and Cinnamic Acid Esters and Their Antioxidant Properties  

作　　者：GAO Yang WANG Bowei GAO Shang ZHANG Ruhui YANG Chunying SUN Zheng LIU Zhihui 

机构地区：[1]School of Stomatology, Capital Medical University, Beijing 100050, P. R. China [2]The Second Hospital of Jilin University, Changchun 130021, P. R. China [3]School of Stomatology, Jilin University, Changchun 130021, P. R. China

出　　处：《Chemical Research in Chinese Universities》2016年第4期594-599,共6页高等学校化学研究（英文版）

摘　　要：In this study, cinnamic acid derivatives with pyridine ring were synthesized via Hantzsch reaction in order to expand conjugation system and their antioxidant abilities were tested. According to the evaluation results of their antioxidant properties, compounds 2 and 3 have similar antioxidant activity to prevent DNA from ＊OH- and Cu2＋/GSH induced oxidation, demonstrating that 1,4-dihydropyridine and pyridine nucleus exhibit good resistance to oxidation while the substituents have little effect. In the meantime, the AAPH-induced oxidative DNA damage [AAPH=2,2＇-azobis（2-methylpropionamidine）dihydrochloride] and trapping ABTS＋＊ test show that N--H bond and large conjugation systems are the pivotal parts to improve the activities of antioxidant.In this study, cinnamic acid derivatives with pyridine ring were synthesized via Hantzsch reaction in order to expand conjugation system and their antioxidant abilities were tested. According to the evaluation results of their antioxidant properties, compounds 2 and 3 have similar antioxidant activity to prevent DNA from ＊OH- and Cu2＋/GSH induced oxidation, demonstrating that 1,4-dihydropyridine and pyridine nucleus exhibit good resistance to oxidation while the substituents have little effect. In the meantime, the AAPH-induced oxidative DNA damage [AAPH=2,2＇-azobis（2-methylpropionamidine）dihydrochloride] and trapping ABTS＋＊ test show that N--H bond and large conjugation systems are the pivotal parts to improve the activities of antioxidant.

关 键 词：Cinnamic acid 1 4-DIHYDROPYRIDINE Free radical OXIDATION ANTIOXIDANT DNA 

分 类 号：TS202.3[轻工技术与工程—食品科学] S432[轻工技术与工程—食品科学与工程]