同步放化疗在头颈部鳞状细胞癌治疗中应用的发展现状  

Present status of concurrent chemoreadiotherapy in squamous cell carcinoma of head and neck

作　　者：李晓明[1] 宋琦[1] 

机构地区：[1]解放军白求恩国际和平医院耳鼻咽喉头颈外科,石家庄050081

出　　处：《中华耳鼻咽喉头颈外科杂志》2016年第7期545-549,共5页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

摘　　要：头颈鳞癌是人体常见的恶性肿瘤,早期头颈鳞癌的治疗可以通过手术和放疗取得较好的治疗效果,但中晚期头颈鳞癌的治疗仍然面临许多困难.由于单一治疗方法,如单纯手术、放疗、化疗等在控制中晚期头颈鳞癌的作用有限,多学科综合治疗已经成为治疗这类肿瘤的重要手段;其中同步放化疗在头颈鳞癌治疗中的应用是近年来的重要进展,其在改善肿瘤预后和重要器官功能保留方面起到了一定作用.本文对同步放化疗的发展历史、作用机制、在头颈鳞癌治疗中应用的适应证及作用、不良反应及不足、今后的发展方向进行了概述,希望对国内头颈鳞癌多学科综合治疗特别是同步放化疗的开展起到一定的指导作用.Head neck squamous cell carcinoma （HNSCC） is a common kind of malignancies in human body.For HNSCC in early stage,either surgical operation or radiotherapy can acquire satisfactory treatment results.However,any single treatment modality such as surgery alone or single radiation is insufficient to gain satisfactory tumor control.Multidisciplinary treatment （MDT） has become a mainstay and important therapeutic strategy in the management of HNSCC.Among various approaches in the MDT,concurrent chemoradiotheraqpy （CCR） constitutes a major progress,which implicates a lot in improving outcomes and organ preservations in managing HNSCC.In the present review,the history,mechanisms,indications along with side effects and drawbacks,and perspectives of CCR are to be described and discussed,in the hope of providing effective guidance for the domestic MDT,especially CCR in the management of HNSCC.

关 键 词：同步放化疗 治疗效果 头颈部鳞状细胞癌 应用 多学科综合治疗 头颈鳞癌 单纯手术 恶性肿瘤 

分 类 号：R739.91[医药卫生—肿瘤]